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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Killinger, Bryan A. Peet, Mary M. Baker, Lisa E. |
| Description | Country affiliation: United States Author Affiliation: Killinger BA ( Department of Psychology, Western Michigan University, Kalamazoo, MI 49008-5439, USA.) |
| Abstract | Salvia divinorum is a small perennial shrub that has gained recent popularity among the drug-using subculture as a legal alternative to hallucinogens. Salvinorin A, the main active compound found in the S.divinorum plant, is an atypical hallucinogen with pharmacological selectivity at kappa opioid (KOP) receptor sites and is a unique non-nitrogenous neoclerodane diterpene which is structurally distinct from other opioid compounds. The novel structure of salvinorin A and its specific binding affinity to KOP receptors provide a unique opportunity to investigate neurochemical mechanisms of hallucination and hallucinogenic compounds. The current investigation assessed the substitution of salvinorin A in 16 male Sprague-Dawley rats trained to discriminate either the prototypical serotonergic hallucinogen, LSD (0.08mg/kg, S.C., n=8) or the dissociative anesthetic and glutamatergic hallucinogen, ketamine (8.0mg/kg, I.P., n=8) from vehicle under a FR 20 schedule of food-reinforced responding. Results indicated that neither LSD nor ketamine discrimination generalized to salvinorin A. These findings are consistent with the growing body of evidence that salvinorin A is pharmacologically distinct from other traditional hallucinogenic compounds. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 3 |
| Volume Number | 96 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Discrimination (psychology) Drug Effects Diterpenes, Clerodane Pharmacology Excitatory Amino Acid Antagonists Hallucinogens Ketamine Lysergic Acid Diethylamide Psychotropic Drugs Animals Conditioning, Operant Data Interpretation, Statistical Discrimination Learning Dose-response Relationship, Drug Male Rats Rats, Sprague-dawley Receptors, N-methyl-d-aspartate Antagonists & Inhibitors Reinforcement Schedule Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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