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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yohn, Samantha E. Santerre, Jessica L. Nunes, Eric J. Kozak, Rouba Podurgiel, Samantha J. Correa, Mercè Salamone, John D. |
| Description | Country affiliation: United States Author Affiliation: Yohn SE ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA.); Santerre JL ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA); Nunes EJ ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA); Kozak R ( Pfizer Research Institute, Eastern Point Road, Groton, CT 06340, USA.); Podurgiel SJ ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA.); Correa M ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA); Salamone JD ( Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. Electronic address: john.salamone@uconn.edu.) |
| Abstract | Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in behavioral activation and effort-related processes. Although much is known about the characteristics of DA D2 receptor antagonism on effort-related choice behavior, less is known about the effects of D1 antagonism, and agonist/antagonist interactions. The highly selective D1 antagonist ecopipam was studied for its effects on effort-related choice behavior using the concurrent fixed ratio (FR) 5/chow feeding choice and T-maze barrier choice procedures. In rats tested on the FR5/chow feeding choice task, ecopipam shifted choice behavior, decreasing lever pressing for preferred high carbohydrate pellets but increasing consumption of lab chow. Also, ecopipam decreased selection of the high effort option (i.e., climbing the barrier to obtain a larger reward) in rats tested on the T-maze task, but did not disrupt arm preference or discrimination when no barrier was present. The D1 agonists SKF38393, SKF81297 and A77636 were assessed for their ability to reverse the effects of ecopipam, and in each case the D1 agonist significantly attenuated the effects of ecopipam, typically with an inverted-u shaped dose/response curve. SKF81297 also was able to reverse the effects of the catecholamine depleting agent tetrabenazine on T-maze performance. In summary, the present results implicate DA D1 receptors in the regulation of behavioral activation and effort-related functions, and demonstrate the utility of using tests of effort-related choice behavior for assessing the effects of D1 agonists. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 135 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Choice Behavior Drug Effects Dopamine Agonists Pharmacology Receptors, Dopamine D1 Adrenergic Uptake Inhibitors Animals Conditioning, Operant Dopamine Antagonists Dose-response Relationship, Drug Feeding Behavior Male Rats Rats, Sprague-dawley Reinforcement Schedule Reward Tetrabenazine Journal Article Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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