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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ohmura, Yu Jutkiewicz, Emily M. Zhang, Andrew Domino, Edward F. |
| Description | Country affiliation: United States Author Affiliation: Ohmura Y ( Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.) |
| Abstract | Abrupt tobacco/nicotine cessation after chronic use causes various withdrawal symptoms/signs. There is evidence that dysfunction of brain dopaminergic system might be responsible for some nicotine withdrawal symptoms. The hypothesis for the present study was that different dopaminergic agonists would relieve different nicotine withdrawal signs. Adult male Sprague-Dawley rats were used. (-)-Nicotine bitartrate (9 mg/kg/day, salt content) or equimolar sodium tartrate was infused into each rat via a subcutaneous (s.c.) osmotic minipump for 7 days. To assess nicotine withdrawal signs, several somatic abstinence signs including teeth-chattering/chews, stretches/gasps, ptosis, shakes, and yawns were counted one day after removal of pumps. These signs were attenuated by the s.c. injection of 0.4 mg/kg nicotine bitartrate. Both a dopamine D(1/5) agonist (SKF81297) and a D(2/3) agonist (pramipexole) relieved abstinence signs dose-dependently but differentially. SKF81297 (0.32 mg/kg, s.c.) reduced teeth-chattering/chews but not shakes. Pramipexole (1mg/kg, s.c.) decreased both teeth-chattering/chews and shakes. A low dose of pramipexole (0.1mg/kg, s.c.) significantly increased yawns, consistent with previous studies that the stimulation of D(3) receptors induces yawning. These results indicate that a D(2)-selective agonist should be considered a candidate to relieve nicotine withdrawal symptoms. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 4 |
| Volume Number | 99 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Dopamine Agonists Pharmacology Receptors, Dopamine D1 Agonists Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D5 Substance Withdrawal Syndrome Drug Therapy Tobacco Use Disorder Analysis Of Variance Animals Behavior, Animal Drug Effects Benzazepines Benzothiazoles Dopamine Metabolism Dose-response Relationship, Drug Drug Implants Injections, Subcutaneous Male Nicotine Administration & Dosage Nicotinic Agonists Rats Rats, Sprague-dawley Psychology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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