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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jaehne, Emily J. Corrigan, Frances Toben, Catherine Jawahar, M. Catharine Baune, Bernhard T. |
| Description | Country affiliation: Australia Author Affiliation: Jaehne EJ ( Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.); Corrigan F ( Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, SA, Australia.); Toben C ( Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.); Jawahar MC ( Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.); Baune BT ( Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia. Electronic address: bernhard.baune@adelaide.edu.au.) |
| Abstract | The atypical antipsychotic drug, quetiapine, has recently been suggested to not only show efficacy in schizophrenia, bipolar, major depressive and general anxiety disorders, but to also have a possible anti-inflammatory effect, which could be important in the treatment of the inflammatory aspects of psychiatric diseases. Male C57BL/6 mice were given either quetiapine (i.p. 10mg/kg), its main active metabolite norquetiapine (i.p. 10mg/kg), or saline as a vehicle control, once a day for 14days. On the 14th day, this dose was followed by a single dose of either LPS (i.p. 1mg/kg) or saline. 24h post LPS short-term recognition memory and anhedonia behaviour were measured using the Y-maze and saccharin preference test respectively. Immediately following behavioural testing, mice were culled before serum, prefrontal cortex and hippocampal analysis of cytokine levels was conducted. It was found that LPS challenge led to increased serum and brain cytokine levels as well as anhedonia, with no significant effect on recognition memory. Quetiapine and norquetiapine both increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the pro-inflammatory cytokine IFN-γ in serum 4h post LPS. Within the brain, a similar pattern was seen in gene expression in the hippocampus at 4h for Il-10 and Ifn-γ, however norquetiapine led to an increase in Il-1ß expression in the PFC at 4h, while both drugs attenuated the increased Il-10 in different regions of the brain at 24h. These effects in the serum and brain, however, had no effect on the observed LPS induced changes in behaviour. Both quetiapine and its metabolite norquetiapine appear to have a partial anti-inflammatory effect on IL-10 and IFN-γ following acute LPS challenge in serum and brain, however these effects did not translate into behavioural changes. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 135 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Anhedonia Drug Effects Antipsychotic Agents Pharmacology Dibenzothiazepines Inflammation Drug Therapy Memory, Short-term Quetiapine Fumarate Animals Behavior, Animal Brain Chemistry Cytokines Metabolism Gene Expression Hippocampus Chemically Induced Interferon-gamma Blood Interleukin-10 Lipopolysaccharides Male Mice Mice, Inbred C57bl Prefrontal Cortex Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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