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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pramila, B. Kalaivani, P. Anita, A. Saravana Babu, C. |
| Description | Author Affiliation: Pramila B ( Centre for Toxicology and Developmental Research, No.1, Ramachandra Nagar, Sri Ramachandra University, Porur, Chennai 600 116, India); Kalaivani P ( Centre for Toxicology and Developmental Research, No.1, Ramachandra Nagar, Sri Ramachandra University, Porur, Chennai 600 116, India. Electronic address: kalaiperiyathambi@gmail.com.); Anita A ( Centre for Toxicology and Developmental Research, No.1, Ramachandra Nagar, Sri Ramachandra University, Porur, Chennai 600 116, India. Electronic address: ramachandra.dranita@gmail.com.); Saravana Babu C ( Centre for Toxicology and Developmental Research, No.1, Ramachandra Nagar, Sri Ramachandra University, Porur, Chennai 600 116, India. Electronic address: ceftpublications@gmail.com.) |
| Abstract | PURPOSE OF RESEARCH: Since, transient focal cerebral ischaemia exhibits detrimental effect not only during the course of ischaemia but also after the onset of reperfusion, the current study is focussed on identifying the appropriate therapeutic time point at which NG-nitro-l-arginine methyl ester (l-NAME) exerts better neuroprotection. PRINCIPAL RESULTS: Pre-ischaemic administration of l-NAME ameliorated neurological deficits much better than the during ischaemic and post-ischaemic groups. Pre-ischaemic l-NAME has also mitigated glutamate excitotoxicity, increased glutamine synthetase activity, ATP and NAD levels, decreased nitrate/nitrite content, down regulated TNF- and upregulated IL-10 expressions and reduced the cerebral infarction significantly than the during ischaemic and post-ischaemic groups. MAJOR CONCLUSION: Current study revealed that l-NAME improved neurological deficit at the pre-ischaemic state in transient focal cerebral ischaemia and has also significantly ameliorated glutamate excitotoxicity. Though l-NAME showed neuroprotective effects when administered at during and post-ischaemia (during reperfusion), it exerts considerable neuroprotection when administered pre-ischaemically. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 135 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Enzyme Inhibitors Therapeutic Use Infarction, Middle Cerebral Artery Drug Therapy Psychology Ng-nitroarginine Methyl Ester Nervous System Diseases Adenosine Triphosphate Metabolism Animals Cerebral Infarction Excitatory Amino Acid Antagonists Pharmacology Glutamate-ammonia Ligase Antagonists & Inhibitors Glutamic Acid Toxicity Complications Interleukin-10 Male Nad Etiology Rats Rats, Sprague-dawley Tumor Necrosis Factor-alpha Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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