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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jatoi, Aminah Ritter, Howard L. Dueck, Amylou Nguyen, Phuong L. Nikcevich, Daniel A. Luyun, Ronnie F. Mattar, Bassam I. Loprinzi, Charles L. |
| Description | Country affiliation: United States Author Affiliation: Jatoi A ( Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA. jatoi.aminah@mayo.edu) |
| Abstract | PURPOSE: This study tested whether infliximab, a chimeric IgG1kappa monoclonal antibody that blocks tumor necrosis factor (TNF) alpha, improves/stabilizes weight loss in elderly and/or poor performance status patients with metastatic non-small cell lung cancer (NSCLC). METHODS: This double-blind trial randomly assigned patients to infliximab/docetaxel (n=32) versus placebo/docetaxel (n=29). The primary endpoint was > or = 10% weight gain. RESULTS: Groups were balanced with respect to age, number of prior chemotherapy regimens, baseline weight loss, and performance status. No patient gained > or = 10% baseline weight, and early evidence of the lack of efficacy prompted early trial closure. Appetite improvement was negligible in both arms. However, infliximab-/docetaxel-treated patients developed greater fatigue and worse global quality of life scores. Other outcomes, such as tumor response rate (<10% in both groups) and overall survival, were not statistically different between groups. There were no statistically significant differences in adverse events, although one death was attributed to infliximab. Genotyping for the TNF alpha -238 and -308 polymorphisms revealed no clinical significance of these genotypes, as relevant to the loss of weight or appetite. CONCLUSIONS: This trial closed early because infliximab did not prevent or palliate cancer-associated weight loss. Infliximab was associated with increased fatigue and inferior global quality of life. |
| File Format | HTM / HTML |
| ISSN | 01695002 |
| Issue Number | 2 |
| Volume Number | 68 |
| e-ISSN | 18728332 |
| Journal | Lung Cancer |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antibodies, Monoclonal Administration & Dosage Carcinoma, Non-small-cell Lung Drug Therapy Physiopathology Lung Neoplasms Weight Loss Drug Effects Aged Aged, 80 And Over Adverse Effects Double-blind Method Fatigue Etiology Female Genetic Association Studies Genotype Humans Infliximab Male Polymorphism, Genetic Quality Of Life Taxoids Tumor Necrosis Factor-alpha Genetics Immunology Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Cancer Research Oncology |
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