NDLI: Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Yuhua Weng, Chu-Chun Tong, Min Wei, Jingyan Tai, Hsin-Hsiung
Description	Country affiliation: United States Author Affiliation: Zhao Y ( Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, United States.)
Abstract	Leukotriene B(4)-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (LTBDH/PGR) is a bifunctional enzyme capable of inactivating leukotriene B(4) (LTB(4)) and 15-oxo-prostaglandins (15-PGs). Its role in growth suppressive functions in lung cancer was studied in in vitro and in vivo systems. The LTBDH/PGR gene was expressed in lung cancer cell lines through recombinant adenovirus infection, and through a tetracycline-inducible expression system. After restoration of LTBDH/PGR expression in LTBDH/PGR-negative (H1299) or -low (A549) lung cancer cell lines, the restored enzyme induced apoptosis and growth inhibition in vitro. Ectopic expression of LTBDH/PGR caused also suppression of tumorigenicity of A549 cells in nude mice. In contrast, LTBDH/PGR over-expression in LTBDH/PGR-positive (H157) lung cancer cell line induced little apoptosis and growth inhibition. This study indicates that restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo.
File Format	HTM / HTML
ISSN	01695002
e-ISSN	18728332
DOI	10.1016/j.lungcan.2009.06.011
Journal	Lung Cancer
Issue Number	2
Volume Number	68
Language	English
Publisher	Elsevier
Publisher Date	2010-05-01
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Discipline Oncology 15-oxoprostaglandin 13-reductase Metabolism Alcohol Oxidoreductases Carcinoma, Non-small-cell Lung Enzymology Cell Proliferation Lung Neoplasms Genetics Animals Pathology Cell Line, Tumor Cloning, Molecular Gene Expression Regulation, Neoplastic Mice Mice, Nude Neoplasm Transplantation Transgenes Tumor Burden Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Cancer Research Oncology

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