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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jeong, Seong Hyun Jung, Jae Ho Han, Jae Ho Kim, Jang Hee Choi, Yong-Won Lee, Hyun Woo Kang, Seok Yun Hwang, Yoon Ho Ahn, Mi Sun Choi, Jin-Hyuk Oh, Young Taek Chun, Mison Kang, Seunghee Park, Kwang Joo Hwang, Sung Chul Sheen, Seung Soo |
| Description | Author Affiliation: Jeong SH ( Department of Hematology-Oncology, Ajou University School of Medicine, Suwon 443-721, Republic of Korea.) |
| Abstract | BACKGROUND: Platinum-based concurrent chemoradiotherapy (CCRT) is a standard treatment for locally advanced unresectable non-small cell lung cancer (NSCLC). The determination of parameters that may predict the result of the treatment has strong clinical implications. PATIENTS AND METHODS: Pretreatment tumor biopsy specimens from 39 patients with locally advanced NSCLC (stage IIIA: 5, stage IIIB: 34) were analyzed for p53, Bcl-2, Bax and ERCC1 expression by immunohistochemistry. All patients were treated with cisplatin-based CCRT. Twenty-four patients received induction chemotherapy followed by CCRT (60Gy/30 fractions, 6mg/m(2) of cisplatin daily). The most commonly administered induction chemotherapy regimen was VIP (etoposide, ifosfamide, cisplatin; 20 patients). Fifteen patients received the same CCRT without induction chemotherapy. RESULTS: High expression of p53, Bcl-2, Bax and ERCC1 was observed in 15 (38%), 19 (49%), 17 (44%) and 12 (31%) patients, respectively. High expression of Bcl-2 was significantly associated with longer survival duration (20 months vs. 9 months, P=0.008) and better response to the treatment (74% vs. 30%, P=0.01). In multivariate analysis, Bcl-2 expression was the only significant independent prognostic factor of overall survival (P=0.007) among the pretreatment patients characteristics. CONCLUSIONS: High expression of Bcl-2 may be a useful prognostic factor in locally advanced NSCLC patients treated with cisplatin-based CCRT. |
| File Format | HTM / HTML |
| ISSN | 01695002 |
| Issue Number | 2 |
| Volume Number | 68 |
| e-ISSN | 18728332 |
| Journal | Lung Cancer |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antineoplastic Agents Administration & Dosage Carcinoma, Non-small-cell Lung Diagnosis Cisplatin Lung Neoplasms Proto-oncogene Proteins C-bcl-2 Metabolism Adult Aged Adverse Effects Mortality Pathology Physiopathology Therapy Dna-binding Proteins Genetics Disease Progression Endonucleases Female Humans Male Middle Aged Prognosis Radiotherapy, Adjuvant Treatment Outcome Tumor Suppressor Protein P53 Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Cancer Research Oncology |
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