NDLI: Molecular profile in body fluids in subjects enrolled in a randomised trial for lung cancer screening: Perspectives of integrated strategies for early diagnosis.

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Molecular profile in body fluids in subjects enrolled in a randomised trial for lung cancer screening: Perspectives of integrated strategies for early diagnosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carozzi, Francesca Maria Bisanzi, Simonetta Falini, Patrizia Sani, Cristina Venturini, Giulia Lopes Pegna, Andrea Bianchi, Roberto Ronchi, Cristina Picozzi, Giulia Mascalchi, Mario Carrozzi, Laura Baliva, Filomena Pistelli, Francesco Tavanti, Laura Falaschi, Fabio Grazzini, Michela Innocenti, Florio Paci, Eugenio
Description	Country affiliation: Italy Author Affiliation: Carozzi FM ( Analytical and Biomolecular Cytology Unit, ISPO Cancer Prevention and Research Institute, Via Cosimo Il Vecchio 2, 50139 Florence, Italy. f.carozzi@ispo.toscana.it)
Abstract	The aim of this study was to evaluate the diagnostic value of a grid of molecular genetic markers detectable in sputum and plasma samples of individuals enrolled in a lung cancer screening program with low-dose CT. Subjects enrolled in the baseline screening round of the ITALUNG (randomised) screening trial were invited to provide biological specimens for molecular analysis (1356 subjects out of 1406). We included 98 subjects in this analysis. There was a highly statistically significant difference between proportion of subjects with a negative baseline CT screening test who were positive to allelic imbalance, and those with a non-calcified nodule (NCN greater than or equal to 5mm), the reason of recall for all suspects at CT Scan (chi(2): 22.9; P<0.0001). Allelic imbalance showed good performance for screening of NCN > or = 5 mm. In subjects recalled for NCN > or = 5 mm, LOH, K-ras mutations and high levels of free plasma DNA (>5ng/ml plasma) might be important to support clinical decision making for further follow-up and repeated screening. This study, embedded in an early diagnosis randomised trial, suggests that a multi-screening approach integrating imaging technique and a biomolecular marker panel is worth of further investigation.
File Format	HTM / HTML
ISSN	01695002
Issue Number	2
Volume Number	68
e-ISSN	18728332
Journal	Lung Cancer
Language	English
Publisher	Elsevier
Publisher Date	2010-05-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Dna Blood Genetic Testing Lung Neoplasms Diagnosis Solitary Pulmonary Nodule Sputum Chemistry Aged Allelic Imbalance Genetics Analysis Dna Mutational Analysis Early Detection Of Cancer Follow-up Studies Genes, Ras Humans Pathology Physiopathology Microsatellite Repeats Middle Aged Prognosis Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Cancer Research Oncology

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Molecular profile in body fluids in subjects enrolled in a randomised trial for lung cancer screening: Perspectives of integrated strategies for early diagnosis.

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