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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tousson, Ehab Rafat, Bassem M. Hessien, Mohamed El Barbary, Ahmed A. Sami, Ahmed |
| Description | Country affiliation: Egypt Author Affiliation: Tousson E ( Department of Zoology, Faculty of Science, Tanta University, Egypt. toussonehab@yahoo.com) |
| Abstract | Lead (Pb) toxicity is one of the commonest environmental problems in our life; it causes many reversible and irreversible changes in our tissues. This study was carried out to investigate the effect of meso-2,3-dimercaptosuccinic acid (DMSA) on treatment of oxidative stress caused by lead poisoning in rabbits. Lead acetate (Pb(Ac)(2)) was orally administrated to rabbits for 21 days and then treated by DMSA for another 21 days. The effect of this treatment was investigated by measuring 2 of the apoptosis proteins p53 and Bcl2. Also, the auto-oxidation rate and their histopathological changes in brain, bone and liver were investigated. Hemoglobin auto-oxidation rate is measured as well as histopathological study of liver. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 proteins. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 3 |
| Volume Number | 27 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2011-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Chelating Agents Therapeutic Use Lead Poisoning Drug Therapy Organometallic Compounds Toxicity Proto-oncogene Proteins C-bcl-2 Metabolism Succimer Tumor Suppressor Protein P53 Animals Bone And Bones Drug Effects Pathology Brain Disease Models, Animal Etiology Liver Male Oxidation-reduction Oxidative Stress Oxyhemoglobins Rabbits Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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