NDLI: Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.

Please wait, while we are loading the content...

Upregulation of CaMKIIÎ´ during ischaemia-reperfusion is associated with reperfusion-induced arrhythmias and mechanical dysfunction of the rat heart: involvement of sarcolemmal Ca2+-cycling proteins.

Adipokines and the cardiovascular system: mechanisms mediating health and disease.

Cyclophilin-A: a potential screening marker for vascular disease in type-2 diabetes.

Thyroid hormone and cardiac repair/regeneration: from Prometheus myth to reality?

The effects of phentolamine on fructose-fed rats.

Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions.

L-cysteine supplementation as an adjuvant therapy for type-2 diabetes.

Implications of protease activation in cardiac dysfunction and development of genetic cardiomyopathy in hamsters.

Implication of multiple signaling pathways in the regulation of angiotensin II induced enhanced expression of Gi proteins in vascular smooth muscle cells.

Cardioprotective and antihypertensive effects of Enicostemma littorale Blume extract in fructose-fed rats.

Regulation of sarco(endo)plasmic reticulum Ca2+-ATPase and calsequestrin gene expression in the heart.

Nutritional aspects of epigenetic inheritance.

Antioxidant characterization of soy derived products in vitro and the effect of a soy diet on peripheral markers of oxidative stress in a heart disease model.

Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.

PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt.

Nutrition and the healthy heart with an exercise boost.

Year: 2012 Volume: 90 Issue: 7

Year: 2012 Volume: 90 Issue: 6

Year: 2012 Volume: 90 Issue: 5

Year: 2012 Volume: 90 Issue: 4

Year: 2012 Volume: 90 Issue: 3

Year: 2012 Volume: 90 Issue: 2

Year: 2012 Volume: 90 Issue: 1

Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maulik, Subir Kumar Prabhakar, Pankaj Dinda, Amit Kumar Seth, Sandeep
Description	Country affiliation: India Author Affiliation: Maulik SK ( Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. skmaulik@gmail.com)
Abstract	Genistein, an isoflavone and a rich constituent of soy, possesses important regulatory effects on nitric oxide (NO) synthesis and oxidative stress. Transient and low release of NO by endothelial nitric oxide synthase (eNOS) has been shown to be beneficial, while high and sustained release by inducible nitric oxide synthase (iNOS) may be detrimental in pathological cardiac hypertrophy. The present study was designed to evaluate whether genistein could prevent isoproterenol-induced cardiac hypertrophy in male Wistar rats (150-200 g, 10-12 weeks old) rats. Isoproterenol (5 mg·(kg body weight)(-1)) was injected subcutaneously once daily for 14 days to induced cardiac hypertrophy. Genistein (0.1 and 0.2 mg·kg(-1), subcutaneous injection once daily) was administered along with isoproterenol. Heart tissue was studied for myocyte size and fibrosis. Myocardial thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase levels, and 1-OH proline (collagen content) were also estimated. Genistein significantly prevented any isoproterenol-induced increase in heart weight to body weight ratio, left ventricular mass (echocardiographic), myocardial 1-OH proline, fibrosis, myocyte size and myocardial oxidative stress. These beneficial effects of genistein were blocked by a nonselective NOS inhibitor (L-NAME), but not by a selective iNOS inhibitor (aminoguanidine). Thus, the present study suggests that the salutary effects of genistein on isoproterenol-induced cardiac hypertrophy may be mediated through inhibition of iNOS and potentiation of eNOS activities.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	8
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-08-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Cardiomegaly Drug Therapy Prevention & Control Cardiotonic Agents Therapeutic Use Genistein Myocardium Metabolism Pathology Animals Chemically Induced Antagonists & Inhibitors Pharmacology Catalase Disease Models, Animal Enzyme Inhibitors Fibrosis Glutathione Guanidines Hydroxyproline Isoproterenol Ng-nitroarginine Methyl Ester Rats, Wistar Superoxide Dismutase Thiobarbituric Acid Reactive Substances Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Protective effect of antioxidants on blood oxidative stress caused by arginine.

The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes.

Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats.

Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation.

Physical training prevents oxidative stress in L-NAME-induced hypertension rats.

(-)Epigallocatechin-gallate (EGCG) prevents mitochondrial damage in isoproterenol-induced cardiac toxicity in albino Wistar rats: a transmission electron microscopic and in vitro study.

Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model.

Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta

Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation.

Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.

Similar Documents

Protective effect of antioxidants on blood oxidative stress caused by arginine.

The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes.

Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats.

Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation.

Physical training prevents oxidative stress in L-NAME-induced hypertension rats.

(-)Epigallocatechin-gallate (EGCG) prevents mitochondrial damage in isoproterenol-induced cardiac toxicity in albino Wistar rats: a transmission electron microscopic and in vitro study.

Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model.

Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta

Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation.

Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.