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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, I-Chieh Hsiao, I-Lun Lin, Ho-Chen Wu, Chien-Hou Chuang, Chun-Yu Huang, Yuh-Jeen |
| Description | Author Affiliation: Chen IC ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: ejchen00@gmail.com.); Hsiao IL ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: ilunshiou@gmail.com.); Lin HC ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: photorice2@gmail.com.); Wu CH ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: chwu@mx.nthu.edu.tw.); Chuang CY ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: cychuang@mx.nthu.edu.tw.); Huang YJ ( Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: yjhuang@mx.nthu.edu.tw.) |
| Abstract | An in vitro blood-brain barrier (BBB) model being composed of co-culture with endothelial (bEnd.3) and astrocyte-like (ALT) cells was established to evaluate the toxicity and permeability of Ag nanoparticles (AgNPs; 8nm) and TiO nanoparticles (TiO NPs; 6nm and 35nm) in normal and inflammatory central nervous system. Lipopolysaccharide (LPS) was pre-treated to simulate the inflammatory responses. Both AgNPs and Ag ions can decrease transendothelial electrical resistance (TEER) value, and cause discontinuous tight junction proteins (claudin-5 and zonula occludens-1) of BBB. However, only the Ag ions induced inflammatory cytokines to release, and had less cell-to-cell permeability than AgNPs, which indicated that the toxicity of AgNPs was distinct from Ag ions. LPS itself disrupted BBB, while co-treatment with AgNPs and LPS dramatically enhanced the disruption and permeability coefficient. On the other hand, TiO NPs exposure increased BBB penetration by size, and disrupted tight junction proteins without size dependence, and many of TiO NPs accumulated in the endothelial cells were observed. This study provided the new insight of toxic potency of AgNPs and TiO NPs in BBB. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 47 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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