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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tian, Qinghai Kaestner, Lars Lipp, Peter |
| Description | Country affiliation: Germany Author Affiliation: Tian Q ( Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, School of Medicine, Saarland University, 66421 Homburg/Saar, Germany.); Kaestner L ( Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, School of Medicine, Saarland University, 66421 Homburg/Saar, Germany.); Lipp P ( Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, School of Medicine, Saarland University, 66421 Homburg/Saar, Germany.) |
| Abstract | Asynchronous release of calcium $(Ca^{2+})—for$ example, the generation of $Ca^{2+}$ alternans in cardiac myocytes—is a phenomenon important in the development of cardiac arrhythmogenesis. The development of a failure to release $Ca^{2+}$ at individual release sites can be regarded as a major contributor to cardiac pathologies such as hypertrophy. Although confocal linescans provide sufficient temporal resolution to investigate the physiological and pathological cardiac excitation–contraction (EC) coupling, linescans can only image ∼1.5% of the cross section of myocytes, which raises doubts about how representative such recordings are, especially in light of nonhomogeneous uncoupling of $Ca^{2+}$ channels and ryanodine receptors. Nowadays, the speed of confocal microscopes has been greatly improved, enabling two-dimensional (2D) imaging at sufficient image rates (>100 frames/sec). To understand better the physiological and pathophysiological EC coupling of cardiomyocytes, we describe here a protocol to monitor fast intracellular $Ca^{2+}$ signals using fast 2D confocal scanning. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 12 |
| Volume Number | 2014 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2014-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Calcium Metabolism Intracellular Space Molecular Imaging Methods Animals Calcium Signaling Cells, Cultured Image Processing, Computer-assisted Microscopy, Confocal Myocytes, Cardiac Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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