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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bito, Virginie Macquaide, Niall Sipido, Karin R. |
| Description | Country affiliation: Belgium Author Affiliation: Bito V ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.); Macquaide N ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.); Sipido KR ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.) |
| Abstract | Here, we describe a method for characterizing the L-type $Ca^{2+}$ current, $I_{CaL},$ which is a major trigger for $Ca^{2+}$ release from the sarcoplasmic reticulum (SR). The protocol includes measuring $I_{CaL}$ amplitude and voltage dependence and the elicited SR $Ca^{2+}$ release. The procedure for measuring $I_{CaL}$ activity is performed using solutions (internal and external) and voltage control such that other ionic currents are eliminated. The resultant relationship between the $Ca^{2+}$ current and the associated internal $[Ca^{2+}]_{i}$ transient is a first approach for evaluating coupling gain. We discuss which parameters are most appropriate for this analysis and how an evaluation of gain needs to be further explored by measuring the SR $Ca^{2+}$ content. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 4 |
| Volume Number | 2015 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Calcium Metabolism Myocytes, Cardiac Sarcoplasmic Reticulum Animals Dogs Mice Sus Scrofa Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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