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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sipido, Karin R. Macquaide, Niall Bito, Virginie |
| Description | Country affiliation: Belgium Author Affiliation: Sipido KR ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.); Macquaide N ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.); Bito V ( Division of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium.) |
| Abstract | In cardiac myocytes, $Ca^{2+}$ release from the sarcoplasmic reticulum (SR) $Ca^{2+}$ store through the opening of ryanodine receptors (RyRs) is the major source of $Ca^{2+}$ for activation of myofilaments and contraction. Over the past 20 years, tools have become available to study this release process in detail, allowing new insights into the regulation of SR $Ca^{2+}$ release and RyR function. To assess these processes, we recommend and here review a systematic approach that evaluates the essential transport mechanisms and $Ca^{2+}$ fluxes in isolated single cardiac myocytes by using fluorescent $Ca^{2+}$ indicators and whole-cell recording of membrane voltage and ionic currents under voltage clamp. The approach includes an assessment of the L-type $Ca^{2+}$ current as a trigger for opening of RyRs and release of SR $Ca^{2+},$ of the SR $Ca^{2+}$ content, of intrinsic properties of RyRs, and of $Ca^{2+}-removal$ systems. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 5 |
| Volume Number | 2015 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Calcium Metabolism Cytological Techniques Methods Myocytes, Cardiac Physiology Optical Imaging Patch-clamp Techniques Muscle Contraction Myofibrils Ryanodine Receptor Calcium Release Channel Staining And Labeling Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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