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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ren, Daoyuan Jiao, Yadong Yang, Xingbin Yuan, Li Guo, Jianjun Zhao, Yan |
| Description | Country affiliation: China Author Affiliation: Ren D ( School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China); Jiao Y ( College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.); Yang X ( College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.); Yuan L ( College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.); Guo J ( College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.); Zhao Y ( School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China. Electronic address: yanzhao@fmmu.edu.cn.) |
| Abstract | Dietary supplement of edible Pleurotus abalonus (P. abalonus) rich in fungal polysaccharides is associated with anticancer health benefit. We here isolated the polysaccharides (PAP) from the fruiting bodies of P. abalonus, and evaluated the antiproliferative activity of the polysaccharides in human colorectal carcinoma LoVo cells. HPLC analysis showed that PAP consisted of D-mannose, D-ribose, l-rhamnose, D-glucuronic acid, D-glucose and D-galactose, and their corresponding mole percentages were 3.4%, 1.1%, 1.9%, 1.4%, 87.9% and 4.4%, respectively. PAP was shown to exert a high antioxidant activity in vitro and a dose-dependent antiproliferative effect against LoVo cancer cells. Flow cytometry analysis demonstrated that PAP exhibited a stimulatory effect on apoptosis of LoVo cells, and induced the cell-cycle arrest at the S phase. We also found that PAP could increase the generation of intracellular ROS which was a critical mediator in PAP-induced cell growth inhibition. These findings suggest that PAP may serve as a potential novel dietary agent for human colon cancer chemoprevention. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Volume Number | 237 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Antineoplastic Agents Pharmacology Antioxidants Pleurotus Chemistry Polysaccharides Isolation & Purification Cell Line, Tumor Chromatography, High Pressure Liquid Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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