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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ferlemi, Anastasia-Varvara Katsikoudi, Antigoni Kontogianni, Vassiliki G. Kellici, Tahsin F. Iatrou, Grigoris Lamari, Fotini N. Tzakos, Andreas G. Margarity, Marigoula |
| Description | Country affiliation: Greece Author Affiliation: Ferlemi AV ( Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, 26504 Rio, Greece.); Katsikoudi A ( Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, 26504 Rio, Greece.); Kontogianni VG ( Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, GR-45110 Ioannina, Greece.); Kellici TF ( Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, GR-45110 Ioannina, Greece); Iatrou G ( Plant Division, Department of Biology, University of Patras, 26504 Rio, Greece.); Lamari FN ( Laboratory of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26504 Patras, Greece.); Tzakos AG ( Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, GR-45110 Ioannina, Greece); Margarity M ( Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, 26504 Rio, Greece. Electronic address: margar@upatras.gr.) |
| Abstract | Our aim was to investigate the possible effects of regular drinking of Rosmarinus officinalis L. leaf infusion on behavior and on AChE activity of mice. Rosemary tea (2% w/w) phytochemical profile was investigated through LC/DAD/ESI-MS(n). Adult male mice were randomly divided into two groups: 'Rosemary-treated' that received orally the rosemary tea for 4weeks and 'control' that received drinking water. The effects of regular drinking of rosemary tea on behavioral parameters were assessed by passive avoidance, elevated plus maze and forced swimming tests. Moreover, its effects on cerebral and liver cholinesterase (ChE) isoforms activity were examined colorimetricaly. Phytochemical analysis revealed the presence of diterpenes, flavonoids and hydroxycinnamic derivatives in rosemary tea; the major compounds were quantitatively determined. Its consumption rigorously affected anxiety/fear and depression-like behavior of mice, though memory/learning was unaffected. ChE isoforms activity was significantly decreased in brain and liver of 'rosemary treated' mice. In order to explain the tissue ChE inhibition, principal component analysis, pharmacophore alignment and molecular docking were used to explore a possible relationship between main identified compounds of rosemary tea, i.e. rosmarinic acid, luteolin-7-O-glucuronide, caffeic acid and known AChE inhibitors. Results revealed potential common pharmacophores of the phenolic components with the inhibitors. Our findings suggest that rosemary tea administration exerts anxiolytic and antidepressant effects on mice and inhibits ChE activity; its main phytochemicals may function in a similar way as inhibitors. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Volume Number | 237 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Anxiety Prevention & Control Brain Enzymology Cholinesterase Inhibitors Pharmacology Cholinesterases Metabolism Depression Liver Rosmarinus Chemistry Tea Animals Computer Simulation Male Mass Spectrometry Mice Mice, Inbred Balb C Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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