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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xin, Tao Zhang, Fubin Jiang, Qiuying Chen, Chunhong Huang, Dayong Lv, Yanju Shen, Weixi Jin, Yinghua |
| Description | Country affiliation: China Author Affiliation: Xin T ( Department of Medical Oncology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China.) |
| Abstract | Two acidic polysaccharide fractions (PTPa and PTPb) extracted from the roots of Polygala tenuifolia, were obtained by DEAE-Sephacel anion-exchange, and Sephadex G-100 gel-permeation chromatography. High-performance liquid chromatography (HPLC) identified that PTPa and PTPb was composed of Ara, Glc, Gal, Man and GlcUA in the proportion of 2.4:1.2:0.6:0.4:1.1 and 2.1:1.7:0.5:0.6:1.7, respectively. Their molecular weight was evaluated to be 5.9×10(4) (PTPa) and 2.5×10(4) Da (PTPb) as determined by high performance size exclusion chromatography (HPSEC). Pharmacological studies revealed PTPa and PTPb significantly inhibited the growth of A549 cells in vitro and exhibited significantly higher antitumor activity against solid tumor A549 in vivo than did a blank control. Moreover, treatment with two acidic polysaccharides caused an enhancement of superoxide dismutase (SOD) and catalase (CAT) activities in tumor-bearing mice and a reduction in thiobarbituric acid reactive substances (TBARS) level. Taken together, these results indicated that two acidic polysaccharides from the roots of P. tenuifolia may be useful as potent antitumor agents for the prevention of lung tumorigenesis. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Issue Number | 4 |
| Volume Number | 90 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-06 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Pharmacology Cell Proliferation Drug Effects Neoplasms, Experimental Drug Therapy Plant Roots Chemistry Polysaccharides Acids Animals Antioxidants Catalase Metabolism Chromatography, Gel Chromatography, High Pressure Liquid Female Humans Mice Mice, Inbred Balb C Mice, Nude Pathology Isolation & Purification Superoxide Dismutase Thiobarbituric Acid Reactive Substances Tumor Cells, Cultured Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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