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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Borman, Evan D. Foster, Warren G. Greenacre, Matthew K. E. Muir, Cameron C. Decatanzaro, Denys |
| Description | Country affiliation: Canada Author Affiliation: Borman ED ( Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada.); Foster WG ( Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.); Greenacre MK ( Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada.); Muir CC ( Department of Psychology, Centre for Neuroscience, Brock University, St. Catharines, Ontario L2S 3A1, Canada.); deCatanzaro D ( Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada. Electronic address: decatanz@mcmaster.ca.) |
| Abstract | Exposure to stress can disrupt blastocyst implantation in inseminated female mice, and evidence implicates elevation of the female's estrogen:progesterone ratio. Exposure to the xenoestrogen, bisphenol A (BPA) can also disrupt implantation. Undisturbed control female CF-1 mice were compared to other females that were exposed to predators (rats) across a wire-mesh grid during gestation days (GD) 1-4, a procedure that elevates corticosterone but does not on its own disrupt implantation in this genetic strain. They were concurrently exposed to varied doses of BPA that on their own were below the threshold dose sufficient to disrupt implantation. On GD 6, we measured the number of intrauterine implantation sites and extracted their uteri, which subsequently were stained and analyzed for uterine luminal area and epithelial cadherin (e-cadherin), a molecule that causes uterine closure and adhesion of blastocysts to the uterine epithelium. The combination of rat-exposure stress and BPA significantly disrupted implantation and increased uterine luminal area, whereas either manipulation on its own did not. E-cadherin was significantly reduced by exposure to BPA, positively correlated with the number of implantation sites, and inversely correlated with luminal area. BPA exposure was also associated with nonmonotonic perturbation of urinary corticosterone concentrations and increased urinary estradiol concentrations on GD 6. These data are consistent with a potential summation of stress-induced estrogen and xenoestrogen activity. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Volume Number | 237 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Benzhydryl Compounds Pharmacology Cadherins Metabolism Embryo Implantation Drug Effects Phenols Uterus Animals Administration & Dosage Dose-response Relationship, Drug Female Male Mice Rats Rats, Long-evans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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