NDLI: Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats.

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Year: 2017 Volume: 89

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Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats.

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Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Illesca, Paola G. Álvarez, Silvina M. Selenscig, Dante A. Ferreira, María Del R. Giménez, María S. Lombardo, Yolanda B. D'Alessandro, María E.
Description	Country affiliation: Argentina Author Affiliation: Illesca PG ( Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, El Pozo CC 242, 3000, Santa Fe, Argentina.); Álvarez SM ( Laboratory of Molecular Biochemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Avenida Ejercito de los Andes 950, 5700, San Luis, Argentina); Selenscig DA ( Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, El Pozo CC 242, 3000, Santa Fe, Argentina.); Ferreira MD ( Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, El Pozo CC 242, 3000, Santa Fe, Argentina); Giménez MS ( Laboratory of Molecular Biochemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Avenida Ejercito de los Andes 950, 5700, San Luis, Argentina); Lombardo YB ( Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, El Pozo CC 242, 3000, Santa Fe, Argentina); D'Alessandro ME ( Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, El Pozo CC 242, 3000, Santa Fe, Argentina)
Abstract	The present study investigates the benefits of the dietary intake of soy protein on adipose tissue dysfunction in a rat model that mimics several aspects of the human metabolic syndrome. Wistar rats were fed a sucrose-rich diet (SRD) for 4 months. After that, half of the animals continued with SRD until month 8 while in the other half, casein protein was replaced by isolated soy protein for 4 months (SRD-S). A reference group consumed a control diet all the time. In adipose tissue we determined: i) the activities of antioxidant enzymes, gene expression of Mn-superoxide dismutase (SOD) and glutathione peroxidase (GPx), and glutathione redox state ii) the activity of xanthine oxidase (XO), ROS levels and the gene expression of NAD(P)H oxidase iii) the expression of the nuclear factor erythroid-2 related factor-2 (Nrf2). Besides, adiposity visceral index, insulin sensitivity, and tumor necrosis factor- (TNF- ) in plasma were determined. Compared with the SRD-fed rats, the animals fed a SRD-S showed: activity normalization of SOD and glutathione reductase, improvement of mRNA SOD and normalization of mRNA GPx without changes in the expression of the Nrf2, and improvement of glutathione redox state. These results were accompanied by a normalization of XO activity and improvement of both the ROS production as well as TNF- levels in plasma. Besides, adipocyte size distribution, adiposity visceral index and insulin sensitivity improved. The results suggest that soy protein can be a complementary nutrient for treating some signs of the metabolic syndrome.
File Format	HTM / HTML
ISSN	07533322
Volume Number	88
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Adipose Tissue Pathology Physiopathology Dietary Proteins Therapeutic Use Dyslipidemias Drug Therapy Insulin Metabolism Oxidative Stress Soybean Proteins Adipocytes Drug Effects Adiposity Animals Antioxidants Biological Markers Body Weight Pharmacology Dietary Sucrose Blood Energy Metabolism Epididymis Glucose Administration & Dosage Glutathione Peroxidase Genetics Male Nf-e2-related Factor 2 Organ Size Protein Carbonylation Rna, Messenger Rats, Wistar Superoxide Dismutase Thiobarbituric Acid Reactive Substances Tumor Necrosis Factor-alpha Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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