NDLI: The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment.

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The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment.

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The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hu, Chenxi Jiang, Xiaodong
Description	Country affiliation: China Author Affiliation: Hu C ( Tumor laboratory, Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University. No. 182, Tongguan Road, Lianyungang City 222002, Jiangsu Province, China.); Jiang X ( Tumor laboratory, Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University. No. 182, Tongguan Road, Lianyungang City 222002, Jiangsu Province, China. Electronic address: jxdysy1970@163.com.)
Abstract	A benefit of anti-angiogenic drugs is improved tumor immune tolerance. Regulatory T cells (Tregs) in the tumor microenvironment mediate tumor immune tolerance and anti-angiogenic drugs not only indirectly affect Tregs via dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) but they can also act directly on Tregs causing immunosuppression. Specifically, these drugs may induce differentiation and chemotaxis and reduce the number and function of Tregs by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) on the cell surface. Recently, anti-angiogenic drugs have been documented to promote a new way of thinking about tumor immunotherapy: clinical application of Tregs and related immunosuppressive molecules may be promising targets for synergistic tumor immunotherapy.
File Format	HTM / HTML
ISSN	07533322
Journal	Biomedicine & Pharmacotherapy
Volume Number	88
e-ISSN	19506007
Language	English
Publisher	Elsevier
Publisher Date	2017-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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