NDLI: Phytosterols as a natural anticancer agent: Current status and future perspective.

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Year: 2017 Volume: 89

Year: 2017 Volume: 88

Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity.

Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.

Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat.

Blocking TGF-ß1 by P17 peptides attenuates gastric cancer cell induced peritoneal fibrosis and prevents peritoneal dissemination in vitro and in vivo.

Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.

Enhanced effect in combination of curcumin- and ketoconazole-loaded methoxy poly (ethylene glycol)-poly (Îµ-caprolactone) micelles.

Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARÎ³, proinflammatory cytokines and oxidative stress.

Heliangin inhibited lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells.

Immune regulatory network in successful pregnancy and reproductive failures.

A systems pharmacology perspective to decipher the mechanism of action of Parangichakkai chooranam, a Siddha formulation for the treatment of psoriasis.

Establishment of a fluorescence-based method to evaluate endocytosis of desialylated glycoproteins in vitro.

Sedative-hypnotic-like effect and molecular docking of di-naphthodiospyrol from Diospyros lotus in an animal model.

l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis.

Hesperetin protects against H O -triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells.

The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment.

Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer.

The mechanism of alopolysaccharide protecting ulceralive colitis.

3',5-dihydroxy-3,4',7-trimethoxyflavone-induces ER-stress-associated HCT-116 programmed cell death via redox signaling.

Exo-organoplasty interventions: A brief review of past, present and future directions for advance heart failure management.

Neuroglobin functions as a prognostic marker and promotes the tumor growth of glioma via suppressing apoptosis.

Protein O-fucosyltransferase 1 promotes trophoblast cell proliferation through activation of MAPK and PI3K/Akt signaling pathways.

Antibacterial activity, computational analysis and host toxicity study of thymol-sulfonamide conjugates.

A mini-review of c-Met as a potential therapeutic target in melanoma.

EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice.

The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy.

p53 dependent apoptosis and cell cycle delay induced by heteroleptic complexes in human cervical cancer cells.

Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells.

Actein ameliorates hepatobiliary cancer through stemness and p53 signaling regulation.

Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation.

Effects of osteogenic protein-1 on intervertebral disc regeneration: A systematic review of animal studies.

Effects of polyphenol compounds melanin on NAFLD/NASH prevention.

The cardioprotective effect of total flavonoids on myocardial ischemia/reperfusion in rats.

MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells.

Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats.

Loss of ErbB2-PI3K/Akt signaling prevents zinc pyrithione-induced cardioprotection during ischemia/reperfusion.

Effect of troxerutin on 2-aminoanthracene and DNA interaction and its anti-mutagenic property.

Cordycepin inhibits airway remodeling in a rat model of chronic asthma.

Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia.

Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation.

The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer.

Y-27632, a Rho-associated protein kinase inhibitor, inhibits systemic lupus erythematosus.

Effects of JS-K, a novel anti-cancer nitric oxide prodrug, on gene expression in human hepatoma Hep3B cells.

Co-delivery of docetaxel and curcumin prodrug via dual-targeted nanoparticles with synergistic antitumor activity against prostate cancer.

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.

Synergy with interferon-lambda 3 and sorafenib suppresses hepatocellular carcinoma proliferation.

Silencing of IRF3 alleviates chronic neuropathic pain following chronic constriction injury.

Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1 cascade.

HCRP1 downregulation promotes hepatocellular carcinoma cell migration and invasion through the induction of EGFR activation and epithelial-mesenchymal transition.

miR-1307 promotes the proliferation of prostate cancer by targeting FOXO3A.

Icariin influences adipogenic differentiation of stem cells affected by osteoblast-osteoclast co-culture and clinical research adipogenic.

MiR-125b inhibits anaplastic thyroid cancer cell migration and invasion by targeting PIK3CD.

SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death.

Sorafenib: A potential therapeutic drug for hepatic fibrosis and its outcomes.

Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat.

Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s).

Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.

Rutin attenuates H O -induced oxidation damage and apoptosis in Leydig cells by activating PI3K/Akt signal pathways.

MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM).

Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentation.

Erianin inhibits indoleamine 2, 3-dioxygenase -induced tumor angiogenesis.

Upregulation of the long non-coding RNA SPRY4-IT1 indicates a poor prognosis and promotes tumorigenesis in ovarian cancer.

MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2.

Camel whey protein improves oxidative stress and histopathological alterations in lymphoid organs through Bcl-XL/Bax expression in a streptozotocin-induced type 1 diabetic mouse model.

A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice.

TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells.

Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway.

Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme.

Elevated expression of KLK8 predicts poor prognosis in colorectal cancer.

The effect of aloe vera on the expression of wound healing factors (TGFß1 and bFGF) in mouse embryonic fibroblast cell: In vitro study.

Dang Gui Bu Xue Tang ameliorates coronary artery ligation-induced myocardial ischemia in rats.

Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice.

Nanotechnology for delivery of gemcitabine to treat pancreatic cancer.

The role of dietary polyphenols in the management of erectile dysfunction-Mechanisms of action.

COMMD7 promotes hepatocellular carcinoma through regulating CXCL10.

Combination of arabinogalactan and curcumin induces apoptosis in breast cancer cells in vitro and inhibits tumor growth via overexpression of p53 level in vivo.

Hepatoprotective role of Ricinus communis leaf extract against d-galactosamine induced acute hepatitis in albino rats.

Gold coated poly (Îµ-caprolactonediol) based polyurethane nanofibers for controlled release of temozolomide.

The efficacy of sulfated polysaccharides from Padina tetrastromatica in modulating the immune functions of RAW 264.7 cells.

Anatomic trisegmentectomy: An alternative treatment for huge or multiple hepatocellular carcinoma of right liver.

Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells.

Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.

Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells.

In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin.

Changes in the expression of -adrenoceptor in peripheral mononuclear cells correlates with blood pressure and plasmatic homocysteine.

LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes.

Prograf produces more benefits for CYP3A5 low expression patients in early stage after kidney transplantation.

URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.

Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress.

Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of astrocytic protein in the hippocampus.

Efficacy of vitamin B complex as an adjuvant therapy for the treatment of complicated vulvovaginal candidiasis: An in vivo and in vitro study.

Long noncoding RNA RP11-766N7.4 functions as a tumor suppressor by regulating epithelial-mesenchymal transition in esophageal squamous cell carcinoma.

Phytosterols as a natural anticancer agent: Current status and future perspective.

The role of IL17B-IL17RB signaling pathway in breast cancer.

Evaluation of anti-osteoporotic activity of butanolic fraction from Passiflora foetida in ovariectomy-induced bone loss in mice.

Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia.

Curcumin and treatment of melanoma: The potential role of microRNAs.

Extraction optimization and in vitro and in vivo anti-postprandial hyperglycemia effects of inhibitor from Phoenix dactylifera L. parthenocarpic fruit.

Immunoprotective activity and antioxidant properties of cactus (Opuntia ficus indica) extract against chlorpyrifos toxicity in rats.

Icariin prevents hypertension-induced cardiomyocyte apoptosis through the mitochondrial apoptotic pathway.

Dose responsive efficacy of umbelliferone on lipid peroxidation, anti-oxidant, and xenobiotic metabolism in DMBA-induced oral carcinogenesis.

Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats.

Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells.

Geraniol alleviates diabetic cardiac complications: Effect on cardiac ischemia and oxidative stress.

Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma.

Hypoglycemic effects of Prunus cerasus L. pulp and seed extracts on Alloxan-Induced Diabetic Mice with histopathological evaluation.

Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells.

Medicinal plants and their isolated compounds showing anti-Trichomonas vaginalis- activity.

Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats.

miR-944 acts as a prognostic marker and promotes the tumor progression in endometrial cancer.

Changes of serum miR34a expression during neoadjuvant chemotherapy predict the treatment response and prognosis in stage II/III breast cancer.

Taraxerol, a pentacyclic triterpene from Abroma augusta leaf, attenuates acute inflammation via inhibition of NF-κB signaling.

T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer.

Agmatine enhances the antidepressant-like effect of lithium in mouse forced swimming test through NMDA pathway.

Vaccinium virgatum fruit extract as an important adjuvant in biochemical and behavioral alterations observed in animal model of metabolic syndrome.

Reference genes for quantitative PCR in the adipose tissue of mice with metabolic disease.

Fundamentals of protein and cell interactions in biomaterials.

25-Hydroxyvitamin D-1- -hydroxylase in apoliporotein E knockout mice: The role of protecting vascular smooth muscle cell from calcification.

Plasma methionine depletion and pharmacokinetic properties in mice of methionine Î³-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes.

Combination of SL327 and Sunitinib Malate leads to an additive anti-cancer effect in doxorubicin resistant thyroid carcinoma cells.

Establishment of a spontaneous metastasis tumor model for human ErbB-2 vaccine.

Impact of bioaccessibility and bioavailability of phenolic compounds in biological systems upon the antioxidant activity of the ethanolic extract of Triplaris gardneriana seeds.

Determination of 16 serum angiogenic factors in stage I non-small cell lung cancer using a bead-based multiplex immunoassay.

Effect of hyperglycemia on brain and liver F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging.

Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats.

Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts.

Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats.

Stem cell, biomaterials and growth factors therapy for hepatocellular carcinoma.

Ethyl acetate fraction of Pteris vittata L. alleviates 2-acetylaminofluorene induced hepatic alterations in male Wistar rats.

Ozone protects rat heart against ischemia-reperfusion injury: A role for oxidative preconditioning in attenuating mitochondrial injury.

Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling.

Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats.

Complexation of phytochemicals with cyclodextrin derivatives - An insight.

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Phytosterols as a natural anticancer agent: Current status and future perspective.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shahzad, Naiyer Khan, Wajahatullah Md, Shadab Ali, Asgar Saluja, Sundeep Singh Sharma, Sadhana Al-Allaf, Faisal A. Abduljaleel, Zainularifeen Ibrahim, Ibrahim Abdel Aziz Abdel-Wahab, Ali Fathi Afify, Mohamed Abdelaziz Al-Ghamdi, Saeed Saeed
Description	Author Affiliation: Shahzad N ( Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. Electronic address: shahzadnaiyer@gmail.com.); Khan W ( Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia.); Md S ( Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Jalil Perkasa, Bukit Jalil, Kuala Lumpur, Malaysia.); Ali A ( Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Patna, India.); Saluja SS ( Department of GI Surgery, GB Pant Hospital, New Delhi, India.); Sharma S ( Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Patna, India.); Al-Allaf FA ( Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.); Abduljaleel Z ( Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.); Ibrahim IA ( Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.); Abdel-Wahab AF ( Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.); Afify MA ( Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.); Al-Ghamdi SS ( Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.)
Abstract	Phytosterols are naturally occurring compounds in plants, structurally similar to cholesterol. The human diet is quite abundant in sitosterol and campesterol. Phytosterols are known to have various bioactive properties including reducing intestinal cholesterol absorption which alleviates blood LDL-cholesterol and cardiovascular problems. It is indicated that phytosterol rich diets may reduce cancer risk by 20%. Phytosterols may also affect host systems, enabling antitumor responses by improving immune response recognition of cancer, affecting the hormone dependent endocrine tumor growth, and by sterol biosynthesis modulation. Moreover, phytosterols have also exhibited properties that directly inhibit tumor growth, including reduced cell cycle progression, apoptosis induction, and tumor metastasis inhibition. The objective of this review is to summarize the current knowledge on occurrences, chemistry, pharmacokinetics and potential anticancer properties of phytosterols in vitro and in vivo. In conclusion, anticancer effects of phytosterols have strongly been suggested and support their dietary inclusion to prevent and treat cancers.
File Format	HTM / HTML
ISSN	07533322
Volume Number	88
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antineoplastic Agents, Phytogenic Pharmacology Neoplasms Drug Therapy Prevention & Control Phytosterols Animals Pharmacokinetics Diet Humans Epidemiology Chemistry Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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