NDLI: Icariin prevents hypertension-induced cardiomyocyte apoptosis through the mitochondrial apoptotic pathway.

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Icariin prevents hypertension-induced cardiomyocyte apoptosis through the mitochondrial apoptotic pathway.

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Icariin prevents hypertension-induced cardiomyocyte apoptosis through the mitochondrial apoptotic pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qian, Zhi-Qiang Wang, Ying-Wan Li, Ye-Li Li, Yi-Qi Yang, Dan-Li
Description	Country affiliation: China Author Affiliation: Qian ZQ ( Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China.); Wang YW ( Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China.); Li YL ( Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China.); Li YQ ( Department of Pharmacology, Zunyi Medical University Zhuhai Campus, Zhuhai, Guangdong, 519041, China.); Ling-Zhu ( Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China.); Yang DL ( Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: 393707603@foxmail.com.)
Abstract	A prior study demonstrated that icariin (ICA) could repress angiotensin II-induced apoptosis in H9c2 cells. The activation of mitochondrial apoptotic pathways may play a crucial role in this phenomenon. In this study, we explored the potential protective roles of ICA in apoptosis in cardiomyocytes, cardiac remodelling, and the underlying mechanisms with regard to the mitochondrial apoptotic pathway in rats with spontaneous hypertension. The oral administration of ICA (20 and 40mg/kg/d) inhibited cardiomyocyte apoptosis and ameliorated left heart ventricle remodelling and abnormal mitochondria. ICA also decreased the blood pressure of model rats. ICA treatment increased the expression of Bcl-2 and decreased the expression of p53, Bax, Bok and cleaved caspase 3 in model rats, which suggests the potential mechanism underlying this effect. In summary, ICA inhibits the apoptosis of cardiomyocytes and ameliorates cardiac remodelling. The potential mechanism may relate to the inhibition of the mitochondrial apoptotic pathway.
File Format	HTM / HTML
ISSN	07533322
Volume Number	88
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Apoptosis Regulatory Proteins Genetics Apoptosis Drug Effects Flavonoids Pharmacology Mitochondria, Heart Myocytes, Cardiac Signal Transduction Angiotensin Ii Toxicity Animals Blood Pressure Cell Line Ultrastructure Rats, Inbred Shr Rats, Inbred Wky Ventricular Remodeling Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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