NDLI: Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.

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Year: 2017 Volume: 89

Year: 2017 Volume: 88

Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity.

Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.

Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat.

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Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peter S., Jerine Basha S., Kadar Giridharan, R. Lavinya B., Udhaya Sabina, Evan Prince
Description	Country affiliation: India Author Affiliation: Peter S J ( School of Biosciences and Technology, VIT University, Vellore, India.); Basha S K ( School of Biosciences and Technology, VIT University, Vellore, India.); Giridharan R ( School of Biosciences and Technology, VIT University, Vellore, India.); Lavinya B U ( School of Biosciences and Technology, VIT University, Vellore, India.); Sabina EP ( School of Biosciences and Technology, VIT University, Vellore, India. Electronic address: eps674@gmail.com.)
Abstract	CONTEXT: The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcer. The aim of this study was to investigate the protective effect of Spirulina fusiformis on Diclofenac-induced toxicity in Wistar albino rats. METHODS: Rats were treated as follows: normal control (group I); diclofenac (50mg/kgb.w., i.p.) treated rats (group II); diclofenac-induced (50mg/kgb.w., i.p.) rats treated with Spirulina fusiformis (400mg/kgb.w., p.o.) (group III); diclofenac-induced (50mg/kgb.w., i.p.) rats treated with silymarin (25mg/kgb.w., p.o.) (group IV); Spirulina fusiformis (400mg/kgb.w., p.o.) alone treated rats (groupV). Biochemical (liver and kidney functional markers) and antioxidant parameters (enzymic and non-enzymic antioxidants) were measured in the blood and tissue homogenates of the rats. Evaluation of intestinal ulcer score and assessment of liver and kidney histology were also done. DISCUSSION: Alterations in the levels of biochemical and antioxidant assays and histopathological changes in liver and kidney proved the toxic effect of diclofenac. The ulcer score was significantly increased in the diclofenac treated rats. Spirulina fusiformis showed to reduce such changes and was able to restore normal antioxidant status in the rats. CONCLUSION: Our study proves the hepato-renal and gastroprotective activity of Spirulina fusiformis in diclofenac-treated rats.
File Format	HTM / HTML
ISSN	07533322
Journal	Biomedicine & Pharmacotherapy
Volume Number	88
e-ISSN	19506007
Language	English
Publisher	Elsevier
Publisher Date	2017-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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