NDLI: Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma.

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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nar, Asli Ozen, Ozlem Tutuncu, Neslihan Bascil Demirhan, Beyhan
Description	Country affiliation: Turkey Author Affiliation: Nar A ( Faculty of Medicine, Department of Endocrinology and Metabolism, Baskent University, 5 sokak No 48, 06490 Bahcelievler, Ankara, Turkey. aslinar@hotmail.com)
Abstract	Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological sections. We studied the expression of cyclin A and cyclin B1 in FNA biopsies and resection specimens of 168 indeterminate or suspicious FNA biopsy results retrospectively at an academic hospital using immunohistochemistry. Malignant histopathology consisted 64 of resection specimens (58 papillary, 4 follicular, 1 medullary, and 1 Hürthle cell carcinoma). Cyclin A was overexpressed in 51.5% of malignant cases in contrast to 31.7% of 104 benign pathology specimens (P = 0.025). Cyclin B1 was positive in 39.1% of malignant specimens in contrast to 15.4% of benign cases (P = 0.001). Cyclin A overexpression was not linked to cyclin B1 overexpression. No association was found between overexpression of cyclin A, cyclin B1 and age, thyroiditis, multifocality, tumor size, extra-thyroidal extension, capsule infiltration, lymph node and distant organ metastases and TNM stage in malignant cases. Female patients with thyroid carcinoma overexpressed significantly more cyclin B1 than male patients (P = 0.015). Retrospective analysis of cyclin A and cyclin B1 in FNA biopsies yielded negative results for both benign and malignant cases. In conclusion, cyclin A and cyclin B1 are useful markers in the distinction of benign and malignant thyroid tumors and can increase diagnostic accuracy.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunohistochemistry Thyroid Neoplasms Tumor Markers, Biological Humans Middle Aged Male Biosynthesis Aged, 80 And Over Biopsy, Fine-needle Metabolism Cyclin B1 Journal Article Young Adult Thyroid Nodule Cyclin A Analysis Adult Female Aged Cell Differentiation Retrospective Studies Diagnosis Neoplasm Staging Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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