NDLI: Late recurrences of gastrointestinal stromal tumours (GISTs) after 5 years of follow-up.

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Late recurrences of gastrointestinal stromal tumours (GISTs) after 5 years of follow-up.

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Late recurrences of gastrointestinal stromal tumours (GISTs) after 5 years of follow-up.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nannini, Margherita Biasco, Guido Pallotti, Maria Caterina Di Battista, Monica Santini, Donatella Paterini, Paola Maleddu, Alessandra Mandrioli, Anna Lolli, Cristian Saponara, Maristella Di Scioscio, Valerio Zompatori, Maurizio Catena, Fausto Fusaroli, Pietro Dei Tos, Angelo Paolo Pantaleo, Maria Abbondanza
Description	Country affiliation: Italy Author Affiliation: Nannini M ( Department of Hematology and Oncology Sciences L A Seragnoli, S Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. maggie.nannini@gmail.com)
Abstract	In practice, relapses of gastrointestinal stromal tumours after long time of surgical resection occur. However, few published data are available for duration, intensity and imaging sources of follow-up in radically excised patients with localized disease. Therefore, every single institution chooses the surveillance schedule according to its experience. The aim of this study was to describe the late recurrences of disease 5 years after the primary tumour's excision in a series of patients with recurrent GIST from our institution. We retrospectively reviewed 42 patients with 'recurrent' GIST, collected since 2001. Ten patients were always followed at our institution, and 32 patients came to our attention at the time of recurrence. The analysed series were divided into two groups: patients who developed recurrence before 5 years and patients who developed recurrence 5 years after the primary tumour's excision. Among 42 patients, 36 patients developed the recurrence within 5 years of the primary tumour excision, whereas 6 patients developed the recurrence 5 years after primary tumour excision diagnosed during follow-up or casually for other reasons. All patients had distant recurrence, involving liver and peritoneum, whereas no local relapse was observed. These patients were heterogeneous in primary tumour site, risk classification and molecular analysis. Duration of the follow-up for radically excised patients with GIST remains still unsettled; however, the integration of every clinical, pathological and molecular parameter is essential to optimize the duration and intensity of the follow-up for each single patient.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Humans Middle Aged Risk Factors Neoplasm Recurrence, Local Male Aged, 80 And Over Journal Article Pathology Receptor, Platelet-derived Growth Factor Alpha Follow-up Studies Adult Female Genetics Aged Retrospective Studies Proto-oncogene Proteins C-kit Discipline Oncology Gastrointestinal Stromal Tumors Dna Mutational Analysis
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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