NDLI: Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.

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Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.

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Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Feng, Zhen-Zhong Chen, Jia-Wei Yang, Zhao-Rui Lu, Guang-Zhong Cai, Zhao-Gen
Description	Country affiliation: China Author Affiliation: Feng ZZ ( Department of Pathology, The First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, 200080 Shanghai, China.)
Abstract	Human pituitary tumor-transforming gene 1 (PTTG1) is a newly identified proto-oncogene, and its overexpression occurs in a wide variety of human cancers. The tumor suppressor gene phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is frequently mutated or deleted in numerous tumors, especially in endometrial carcinoma. The aim of this study was to investigate whether the aberrant expression of PTTG1 and PTEN is associated with tumorigenesis and progression of endometrial carcinoma. Tissue microarray and immunohistochemical staining were undertaken in 124 endometrial carcinoma, 28 atypical hyperplasia and 35 normal endometrium samples. Then, the correlation of PTTG1 and PTEN expression with the clinicopathological features and with the levels of estrogen and progesterone receptor was analyzed. The presence of PTTG1 and PTEN protein was significantly increased and decreased, respectively, as lesions progressed from normal endometrium to atypical hyperplasia to carcinoma. PTTG1 protein showed a significantly positive correlation with TNM stage, but not with other characteristics. In addition, PTEN protein did not correlate with any parameters except for histological grade, to which it was found to be inversely related. Statistical analysis confirmed a significant relationship between an increase in PTTG1 and a decrease in PTEN. These results indicate that high expression of PTTG1 and low expression of PTEN may be involved in pathogenesis and development of endometrial carcinoma. The findings also provide evidence that combined evaluation of the two markers may be useful in predicting tumor behavior and thus prognosis.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunohistochemistry Tissue Array Analysis Humans Hyperplasia Middle Aged Biosynthesis Endometrial Neoplasms Journal Article Neoplasm Grading Neoplasm Proteins Adult Female Retrospective Studies Securin Discipline Oncology Tumor Markers, Biological Metabolism Aged, 80 And Over Disease Progression Pathology Pten Phosphohydrolase Analysis Aged Neoplasm Staging Precancerous Conditions
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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