NDLI: Fatal interstitial lung disease associated with gemcitabine and erlotinib therapy for lung cancer.

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Fatal interstitial lung disease associated with gemcitabine and erlotinib therapy for lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nasrallah, Haitam Bar-Sela, Gil Haim, Nissim
Description	Country affiliation: Israel Author Affiliation: Nasrallah H ( Division of Oncology, Rambam Health Care Campus and Faculty of Medicine, Technion-Israel Institute of Technology, POB 9602, Haifa 31096, Israel.)
Abstract	Gemcitabine in combination with the oral epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, is a treatment option for patients with advanced pancreatic cancer. Lung toxicity has been described for each of these drugs. A 59-year-old man with advanced non-small-cell lung cancer developed acute respiratory failure with bilateral interstitial lung disease 4 weeks after the onset of second-line combination therapy that included gemcitabine and erlotinib. Despite discontinuation of gemcitabine and erlotinib, treatment with corticosteroids was ineffective and the patient gradually deteriorated and died with progressive respiratory failure 2 months after the start of the gemcitabine/erlotinib combination. It was concluded that a synergistic effect between gemcitabine and erlotinib could have been responsible for this fatal pulmonary toxicity. Physicians should be aware of the potential severe lung toxicity of this combination. The potential role of corticosteroids in the management of this toxicity is unknown.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Erlotinib Hydrochloride Adverse Effects Humans Middle Aged Drug Therapy Antineoplastic Combined Chemotherapy Protocols Male Administration & Dosage Quinazolines Lung Neoplasms Chemically Induced Journal Article Physiopathology Case Reports Deoxycytidine Fatal Outcome Carcinoma, Non-small-cell Lung Lung Diseases, Interstitial Discipline Oncology Analogs & Derivatives
Content Type	Text
Resource Type	Case study Article
Subject	Hematology Cancer Research Oncology

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