NDLI: Residual shunt after patent foramen ovale closure: preliminary results from Italian patent foramen ovale survey.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Caputi, Luigi Butera, Gianfranco Anzola, Gian Paolo Carminati, Mario Carriero, Maria Rita Chessa, Massimo Onorato, Eustaquio Rigatelli, Gianluca Sangiorgi, Giuseppe Santoro, Gennaro Spadoni, Isabella Ussia, Gian Paolo Vigna, Carlo Zanchetta, Mario Parati, Eugenio
Spatial Coverage	Italy
Description	Author Affiliation: Caputi L ( Department of Cerebrovascular Diseases, Fondazione Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Neurological Institute C. Besta, Milan, Italy. Electronic address: lcaputi@istituto-besta.it.)
Abstract	BACKGROUND: Percutaneous patent foramen ovale (PFO) closure is accepted as treatment for cryptogenic ischemic stroke/transient ischemic attack in young subjects. However, a thorough evaluation of residual right-to-left shunt (rRLS) after PFO closure is needed. Our aims were to analyze the characteristics related to PFO diagnosis and closure, focusing on rRLS and clinical recurrences until 24-month follow-up. Data were extrapolated from the 12-month Italian PFO Survey. METHODS: In all, 1035 patients were included. PFO diagnosis and right-to-left shunt (RLS) were assessed by contrast-enhanced transesophageal and/or transthoracic echocardiography and/or transcranial Doppler. RESULTS: PFO diagnosis with RLS data were available in 894 of 1035 (86.4%) patients. rRLS was investigated in 49.6% (6 months), 27.1% (12 months), and 3.5% (24 months), and observed in 19.5% (6 months) and 18.2% (12 months) of subjects. Large permanent rRLS was observed in less than 3% of RLS-positive patients after 1 year. Eleven of 14 and 3 of 14 neurological recurrences were observed in 10 of 444 (2.25%) and 2 of 243 (0.8%) patients within the 6- and 12-month follow-up, respectively. Among these, no large rRLS was reported. There were no neurological events at 2-year follow-up. Forty of 444 subjects had non-neurological complications, mostly cardiac arrhythmias within the sixth month. CONCLUSIONS: PFO closure is a safe procedure. rRLS is not uncommon but large rRLS is rare. Clinical complications, mostly related to cardiac arrhythmias, are not unusual. Evaluation of the data of the whole survey is underway.
File Format	HTM / HTML
ISSN	10523057
Issue Number	7
Volume Number	22
e-ISSN	15328511
Journal	Journal of Stroke and Cerebrovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Recurrence Humans Middle Aged Child, Preschool Male Treatment Outcome Foramen Ovale, Patent Journal Article Discipline Cardiology Surgery Follow-up Studies Adolescent Ultrasonography Adult Female Italy Registries Aged Child
Content Type	Text
Resource Type	Article
Subject	Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine

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