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Treatment outcomes of tissue plasminogen activator infusion for branch atheromatous disease.

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Treatment outcomes of tissue plasminogen activator infusion for branch atheromatous disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deguchi, Ichiro Hayashi, Takeshi Kato, Yuji Nagoya, Harumitsu Ohe, Yasuko Fukuoka, Takuya Maruyama, Hajime Horiuchi, Yohsuke Tanahashi, Norio
Description	Author Affiliation: Deguchi I ( Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Saitama, Japan. Electronic address: ideguchi@saitama-med.ac.jp.)
Abstract	BACKGROUND: The objective of this study was to evaluate treatment outcomes of tissue plasminogen activator (t-PA) infusion for hyperacute branch atheromatous disease (BAD) within 3 hours after onset. METHODS: A total of 152 BAD patients with lenticulostriate artery (LSA) or paramedian pontine artery (PPA) territory infarcts (LSA 114; PPA 38) were hospitalized between April 2007 and June 2012. Of these, 21 BAD patients (LSA 19; PPA 2) arrived at the hospital within 3 hours after onset, and, among these, 8 patients who received t-PA infusion (.6 mg/kg) were included in this study. All BAD patients who received t-PA infusion had LSA territory infarcts. RESULTS: Six of 8 patients (75%) had improvement of neurologic findings within 60 minutes after t-PA infusion, but neurologic findings deteriorated within 24 hours in 4 of these patients (67%). In all patients with deterioration, diffusion-weighted imaging after 24 hours revealed infarct expansion. One patient (13%) had symptomatic intracranial hemorrhage. After 3 months, the modified Rankin Scale (mRS) score was 0 to 2 in 6 patients (75%) and 3 to 6 in 2 patients (25%). CONCLUSIONS: With t-PA infusion for BAD, symptoms transiently improved, but the rate of symptom deterioration was high. The outcome after 3 months was relatively good.
File Format	HTM / HTML
ISSN	10523057
Issue Number	7
Volume Number	22
e-ISSN	15328511
Journal	Journal of Stroke and Cerebrovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brain Ischemia Stroke Humans Middle Aged Drug Therapy Male Treatment Outcome Administration & Dosage Fibrinolytic Agents Aged, 80 And Over Therapeutic Use Middle Cerebral Artery Journal Article Physiopathology Tissue Plasminogen Activator Discipline Cardiology Thrombolytic Therapy Diffusion Magnetic Resonance Imaging Adult Female Aged Infusions, Intravenous
Content Type	Text
Resource Type	Article
Subject	Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine

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