NDLI: Stroke scale items associated with neurologic deterioration within 24 hours after recombinant tissue plasminogen activator therapy.

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Stroke scale items associated with neurologic deterioration within 24 hours after recombinant tissue plasminogen activator therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nanri, Yusuke Yakushiji, Yusuke Hara, Megumi Eriguchi, Makoto Okada, Ryuichirou Yukitake, Motohiro Hara, Hideo
Description	Author Affiliation: Nanri Y ( Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. Electronic address: nanriyu@cc.saga-u.ac.jp.)
Abstract	It is unclear when and which neurologic deficits should be examined within 24 hours after intravenous recombinant tissue plasminogen activator (rt-PA) therapy for acute ischemic stroke. Relationships between serial changes in National Institutes of Health Stroke Scale (NIHSS) subscores and neurologic deterioration (ND) within the first 24 hours after therapy were investigated in 43 consecutive patients. The NIHSS score was measured by neurologists 28 times within 24 hours after therapy. Assessments of subscores associated with ND, defined as the first change 4 or more points from baseline, were performed at 15 minutes (most frequent time of the first ND), 120 minutes (median time of the first ND), and 24 hours after therapy. Seventeen of 43 patients (age range, 55-94 years) showed ND. Of the NIHSS subscores, increases in scores for loss of consciousness (15 minutes, P = .001; 120 minutes, P = .026; 24 hours, P = .018) and motor limbs total (15 minutes, P = .014; 120 minutes, P = .031) were related to deterioration. Items such as questions, gaze, visual fields, ataxia, language, dysarthria, and extinction/inattention were not related to deterioration at any time. In conclusion, ND of ischemic stroke patients treated with intravenous rt-PA therapy was frequently seen within 120 minutes after therapy. Items such as loss of consciousness and motor limbs total may be considered indices for monitoring neurologic deficits after therapy.
File Format	HTM / HTML
ISSN	10523057
Issue Number	7
Volume Number	22
e-ISSN	15328511
Journal	Journal of Stroke and Cerebrovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brain Ischemia Humans Middle Aged Male Journal Article Time Factors Etiology Discipline Cardiology Ataxia Female Diagnosis Severity Of Illness Index Stroke Adverse Effects Unconsciousness Complications Drug Therapy Treatment Outcome Fibrinolytic Agents Aged, 80 And Over Therapeutic Use Tissue Plasminogen Activator Neurologic Examination Thrombolytic Therapy Aged Infusions, Intravenous
Content Type	Text
Resource Type	Article
Subject	Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine

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