NDLI: Telomere length in peripheral blood mononuclear cells is associated with folate status in men.

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Telomere length in peripheral blood mononuclear cells is associated with folate status in men.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Paul, Ligi Cattaneo, Marco D'Angelo, Armando Sampietro, Francesca Fermo, Isabella Razzari, Cristina Fontana, Gessica Eugene, Nindra Jacques, Paul F. Selhub, Jacob
Description	Country affiliation: United States Author Affiliation: Paul L ( Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. ligi.paul_pottenplackel@tufts.edu)
Abstract	Human chromosomes are capped by telomeres, which consist of tandem repeats of DNA and associated proteins. The length of the telomeres is reduced with increasing cell divisions except when the enzyme telomerase is active, as in stem cells and germ cells. Telomere dysfunction has been associated with development of age-related pathologies, including cancer, cardiovascular disease, Alzheimer's disease, and Parkinson's disease. DNA damage in the telomeric region causes attrition of telomeres. Because folate provides precursors for nucleotide synthesis and thus affects the integrity of DNA, including that of the telomeric region, folate status has the potential to influence telomere length. Telomere length is epigenetically regulated by DNA methylation, which in turn could be modulated by folate status. In this study, we determined whether folate status and the 677C > T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene are associated with the telomere length of peripheral blood mononuclear cells in healthy men. The results of our study showed that plasma concentration of folate was associated with telomere length of peripheral blood mononuclear cells in a nonlinear manner. When plasma folate concentration was above the median, there was a positive relationship between folate and telomere length. In contrast, there was an inverse relationship between folate and telomere length when plasma folate concentration was below the median. The MTHFR 677C > T polymorphism was weakly associated (P = 0.065) with increased telomere length at below-median folate status. We propose that folate status influences telomere length by affecting DNA integrity and the epigenetic regulation of telomere length through DNA methylation.
File Format	HTM / HTML
ISSN	00223166
Issue Number	7
Volume Number	139
e-ISSN	15416100
Journal	Journal of Nutrition
Language	English
Publisher	American Society for Nutrition
Publisher Date	2009-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Folic Acid Rna Humans Cytology Cell Aging Genotype Male Leukocytes, Mononuclear Metabolism Telomere Blood Journal Article Beta-globins Ultrastructure Dna Polymerase Chain Reaction Vitamin B 12 Genetics Polymorphism, Single Nucleotide Discipline Nutrition Homocysteine Methylenetetrahydrofolate Reductase (nadph2)
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents.

The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism.

MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.

Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.

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Effect of the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods.

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Telomere length in peripheral blood mononuclear cells is associated with folate status in men.

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Telomere length in peripheral blood mononuclear cells is associated with folate status in men.