NDLI: Zinc supplementation increases zinc status and thymopoiesis in aged mice.

Please wait, while we are loading the content...

Dietary Echium oil increases tissue (n-3) long-chain polyunsaturated fatty acids without elevating hepatic lipid concentrations in premature neonatal rats.

Caregiver verbal encouragement increases food acceptance among Vietnamese toddlers.

Analytical recovery of folate degradation products formed in human serum and plasma at room temperature.

Impaired ghrelin response after high-fat meals is associated with decreased satiety in obese and lean Chinese young adults.

A traditional rice and beans pattern is associated with metabolic syndrome in Puerto Rican older adults.

Telomere length in peripheral blood mononuclear cells is associated with folate status in men.

Consuming functional foods enriched with plant sterol or stanol esters for 85 weeks does not affect neurocognitive functioning or mood in statin-treated hypercholesterolemic individuals.

Proapoptotic Effects of Dietary (n-3) Fatty Acids Are Enhanced in Colonocytes of Manganese-Dependent Superoxide Dismutase Knockout Mice

Simulation model accurately estimates total dietary iodine intake.

Patterns of recommended dietary behaviors predict subsequent risk of mortality in a large cohort of men and women in the United States.

Intestinal Physiology and Peptidase Activity in Male Pigs Are Modulated by Consumption of Corn Culture Extracts Containing $Fumonisins^{1–3}$

Zinc supplementation increases zinc status and thymopoiesis in aged mice.

Diet Calcium Level but Not Calcium Supplement Particle Size Affects Bone Density and Mechanical Properties in Ovariectomized $Rats^{1},^{2}$

Prebiotics modulate immune responses in the gut-associated lymphoid tissue of chickens.

Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.

Dietary L-homoserine spares threonine in chicks.

Cow milk allergy symptoms are reduced in mice fed dietary synbiotics during oral sensitization with whey.

alpha-Lactalbumin hydrolysate stimulates glucagon-like peptide-2 secretion and small intestinal growth in suckling rats.

Decreasing trends in malnutrition prevalence rates explained by regular audits and feedback.

Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.

Quercetin administration ameliorates pulmonary complications of cirrhosis in rats.

Conjugated linoleic acids reduce body fat in healthy postmenopausal women.

The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition.

Year: 2009 Volume: 139 Issue: 6

Year: 2009 Volume: 139 Issue: 5

Year: 2009 Volume: 139 Issue: 4

Year: 2009 Volume: 139 Issue: 3

Year: 2009 Volume: 139 Issue: 2

Year: 2009 Volume: 139 Issue: 1

Year: 2008 Volume: 138

Year: 2007 Volume: 137

Zinc supplementation increases zinc status and thymopoiesis in aged mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wong, Carmen P. Song, Yang Elias, Valerie D. Magnusson, Kathy R. Ho, Emily
Description	Country affiliation: United States Author Affiliation: Wong CP ( Department of Nutrition and Exercise Sciences, Oregon State University, OR 97331, USA.)
Abstract	The age-related decline in lymphocyte development and function coincides with impaired zinc status in the elderly. Thymic involution and reduced immune responsiveness are classic hallmarks of both aging and zinc deficiency, resulting in decreased host defense and an increased susceptibility to infections. Thus, compromised zinc status associated with aging may be an important contributing factor in reduced thymopoiesis and impaired immune functions. Our goal in this study was to understand how dietary zinc supplementation affects thymopoiesis in aged mice. We hypothesized that impaired zinc status associated with aging would mediate the decline in thymic function and output and that restoring plasma zinc concentrations via zinc supplementation would improve thymopoiesis and thymic functions. In this study, groups of young (8 wk) and aged (22 mo) mice were fed a zinc-adequate (30 mg/kg zinc) or zinc-supplemented diet (300 mg/kg) for 25 d. Aged mice had impaired zinc status, with zinc supplementation restoring plasma zinc to a concentration not different from those of young male C57Bl/6 mice. Zinc supplementation in aged mice improved thymopoiesis, as assessed by increased total thymocyte numbers. In addition, improved thymic output was mediated in part by reducing the age-related accumulation of immature CD4(-)CD8(-)CD44(+)CD25(-) thymocytes, as well as by decreasing the expression of stem cell factor, a thymosuppressive cytokine. Taken together, our results showed that in mice, zinc supplementation can reverse some age-related thymic defects and may be of considerable benefit in improving immune function and overall health in elderly populations.
File Format	HTM / HTML
ISSN	00223166
e-ISSN	15416100
DOI	10.3945/jn.109.106021
Journal	Journal of Nutrition
Issue Number	7
Volume Number	139
Language	English
Publisher	American Society for Nutrition
Publisher Date	2009-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Thymus Gland Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Body Weight Rna, Ribosomal, 18s Cytology Blood Interleukin-6 Polymerase Chain Reaction Aging Genetics Physiology Mice, Inbred C57bl Pharmacology Administration & Dosage Metabolism Drug Effects Zinc Animals Mice Discipline Nutrition Dietary Supplements Stem Cell Factor Animal Feed
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice.

Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice.

The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice.

Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

Prolonged intake of coenzyme Q10 impairs cognitive functions in mice.

White button, portabella, and shiitake mushroom supplementation up-regulates interleukin-23 secretion in acute dextran sodium sulfate colitis C57BL/6 mice and murine macrophage J.744.1 cell line.

Catechin-rich grape seed extract supplementation attenuates diet-induced obesity in C57BL/6J mice.

Zinc, metallothioneins and immunosenescence.

Zinc Supplementation Increases Zinc Status and Thymopoiesis in Aged Mice1 2

Zinc supplementation increases zinc status and thymopoiesis in aged mice.

Similar Documents

Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice.

Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice.

The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice.

Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

Prolonged intake of coenzyme Q10 impairs cognitive functions in mice.

White button, portabella, and shiitake mushroom supplementation up-regulates interleukin-23 secretion in acute dextran sodium sulfate colitis C57BL/6 mice and murine macrophage J.744.1 cell line.

Catechin-rich grape seed extract supplementation attenuates diet-induced obesity in C57BL/6J mice.

Zinc, metallothioneins and immunosenescence.

Zinc Supplementation Increases Zinc Status and Thymopoiesis in Aged Mice1 2

Zinc supplementation increases zinc status and thymopoiesis in aged mice.