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Conjugated linoleic acids reduce body fat in healthy postmenopausal women.

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Conjugated linoleic acids reduce body fat in healthy postmenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Raff, Marianne Tholstrup, Tine Toubro, Søren Bruun, Jens M. Lund, Pia Straarup, Ellen M. Christensen, Robin Sandberg, Maria B. Mandrup, Susanne
Description	Country affiliation: Denmark Author Affiliation: Raff M ( Department of Human Nutrition, Faculty of Life, University of Copenhagen, Frederiksberg 1958, Denmark. mrf@life.ku.dk)
Abstract	Isomers of conjugated linoleic acids (CLA) reduce fat mass (FM) and increase insulin sensitivity in some, but not all, murine studies. In humans, this effect is still debatable. In this study, we compared the effect of 2 CLA supplements on total and regional FM assessed by dual energy X-ray absorptiometry, changes in serum insulin and glucose concentrations, and adipose tissue (AT) gene expression in humans. In a double-blind, parallel, 16-wk intervention, we randomized 81 healthy postmenopausal women to 1) 5.5 g/d of 40/40% of cis9,trans11-CLA (c9,t11-CLA) and trans10,cis12-CLA (t10,c12-CLA) (CLA-mix); 2) cis9, trans11-CLA (c9,t11-CLA); or 3) control (olive oil). We assessed all variables before and after the intervention. The CLA-mix group had less total FM (4%) and lower-body FM (7%) than the control (P = 0.02 and < 0.001, respectively). Post hoc analyses showed that serum insulin concentrations were greater in the CLA-mix group (34%) than the control group (P = 0.02) in the highest waist circumference tertile only. AT mRNA expression of glucose transporter 4, leptin, and lipoprotein lipase was lower, whereas expression of tumor necrosis factor-alpha was higher in the CLA-mix group than in the control group (P < 0.04). In conclusion, a 50:50 mixture of c9,t11- and t10,c12-CLA isomers resulted in less total and lower-body FM in postmenopausal women and greater serum insulin concentrations in the highest waist circumference tertile. Future research is needed to confirm the insulin desensitizing effect of the CLA mixture and the effect on the mRNA expression of adipocyte-specific genes in humans.
File Format	HTM / HTML
ISSN	00223166
Issue Number	7
Volume Number	139
e-ISSN	15416100
Journal	Journal of Nutrition
Language	English
Publisher	American Society for Nutrition
Publisher Date	2009-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Linoleic Acids, Conjugated Research Support, Non-u.s. Gov't Body Weight Fatty Acids Humans Olive Oil Blood Journal Article Adiponectin Questionnaires Postmenopause Female Genetics Plant Oils Adipose Tissue Anatomy & Histology Rna, Messenger Blood Glucose Pharmacology Metabolism Randomized Controlled Trial Drug Effects Insulin Tumor Necrosis Factor-alpha Waist Circumference Patient Compliance Discipline Nutrition Health Status
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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