NDLI: Analytical recovery of folate degradation products formed in human serum and plasma at room temperature.

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Analytical recovery of folate degradation products formed in human serum and plasma at room temperature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hannisdal, Rita Ueland, Per Magne Eussen, Simone J. P. M. Svardal, Asbjørn Hustad, Steinar
Description	Country affiliation: Norway Author Affiliation: Hannisdal R ( Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen 5021, Norway. rita.hannisdal@farm.uib.no)
Abstract	Folate is not stable in serum and plasma. This may impair laboratory diagnostics and distort the outcome of epidemiological studies on folate and chronic diseases. The present study was designed to determine the kinetics of folate loss in human serum and plasma (collected into tubes containing EDTA, heparin, or citrate) at room temperature and the recovery of folate as 4-alpha-hydroxy-5-methyltetrahydrofolate (hmTHF) or p-aminobenzoylglutamate (pABG) equivalents. Different folate species and pABG were determined by liquid chromatography-tandem MS and microbiologically active folate was measured by a Lactobacillus rhamnosus assay. Concentrations of 5mTHF and microbiologically active folate had a parallel and rapid decrease in EDTA plasma to approximately 60% of the initial concentration after 24 h. In serum, heparin plasma, and citrate plasma, folate decreased more slowly to approximately 50% after 192 h. The loss of 5mTHF that occurred within 48 h was totally recovered as hmTHF. Folate measured as pABG equivalents decreased slowly to approximately 80% in 192 h and the decline was essentially matrix independent. In conclusion, the degradation of 5mTHF and microbiologically active folate in serum and plasma at room temperature can largely be corrected for by determining hmTHF or measuring folate as pABG equivalents. Moreover, results obtained using conventional folate assays may be biased by improper sample handling or if samples contained high concentrations of hmTHF.
File Format	HTM / HTML
ISSN	00223166
Issue Number	7
Volume Number	139
e-ISSN	15416100
Journal	Journal of Nutrition
Language	English
Publisher	American Society for Nutrition
Publisher Date	2009-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Folic Acid Temperature Citrates Drug Stability Humans Isolation & Purification Edetic Acid Metabolism Blood Journal Article Heparin Kinetics Discipline Nutrition Glutamates Analogs & Derivatives
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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