NDLI: Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Obadan, Adebimpe O. Kimble, Brian J. Rajao, Daniela Lager, Kelly Santos, Jefferson J. S. Vincent, Amy Perez, Daniel R.
Description	Country affiliation: United States Author Affiliation: Obadan AO ( 1âVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.); Kimble BJ ( 1âVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.); Rajao D ( 2âVirus and Prion Diseases Unit, National Animal Disease Center, USDA-ARS, Ames, IA, USA.); Lager K ( 2âVirus and Prion Diseases Unit, National Animal Disease Center, USDA-ARS, Ames, IA, USA.); Santos JJ ( 1âVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.); Vincent A ( 2âVirus and Prion Diseases Unit, National Animal Disease Center, USDA-ARS, Ames, IA, USA.); Perez DR ( 1âVirginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.)
Abstract	Influenza A virus is a major pathogen of birds, swine and humans. Strains can jump between species in a process often requiring mutations and reassortment, resulting in outbreaks and, potentially, pandemics. H9N2 avian influenza is predominant in poultry across Asia and occasionally infects humans and swine. Pandemic H1N1 (H1N1pdm) is endemic in humans and swine and has a history of reassortment in pigs. Previous studies have shown the compatibility of H9N2 and H1N1pdm for reassortment in ferrets, a model for human infection and transmission. Here, the effects of ferret adaptation of H9 surface gene segments on the infectivity and transmission in at-risk natural hosts, specifically swine and quail, were analysed. Reassortant H9N1 and H9N2 viruses, carrying seven or six gene segments from H1N1pdm, showed infectivity and transmissibility in swine, unlike the wholly avian H9N2 virus with ferret-adapted surface genes. In quail, only the reassortant H9N2 with the six internal gene segments from the H1N1pdm strain was able to infect and transmit, although less efficiently than the wholly avian H9N2 virus with ferret-adapted surface genes. These results highlight that ferret-adapted mutations on the haemagglutinin of H9 subtype virus do not restrict the ability of the virus to infect swine and quail, and that the ability to transmit in these species depends on the context of the whole virus. As such, this study emphasizes the threat that H9N2 reassortant viruses pose to humans and agricultural species and the importance of the genetic constellation of the virus to its ability to replicate and transmit in natural hosts of influenza.
File Format	HTM / HTML
ISSN	00221317
e-ISSN	14652099
DOI	10.1099/vir.0.000190
Journal	Journal of General Virology
Issue Number	9
Volume Number	96
Language	English
Publisher	Microbiology Society
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Virulence Transmission Influenza A Virus, H1n1 Subtype Viral Proteins Swine Influenza A Virus, H9n2 Subtype Genetics Physiology Orthomyxoviridae Infections Research Support, U.s. Gov't, Non-p.h.s. Cell Line Discipline Virology Swine Diseases Ferrets Quail Metabolism Virology Pathogenicity Animals Virus Replication Influenza, Human Reassortant Viruses Veterinary Influenza In Birds
Content Type	Text
Resource Type	Article
Subject	Virology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Viral reassortment and transmission after co-infection of pigs with classical H1N1 and triple-reassortant H3N2 swine influenza viruses

Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses

Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail

New reassortant and enzootic European swine influenza viruses transmit efficiently through direct contact in the ferret model

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice

Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail

Similar Documents

Viral reassortment and transmission after co-infection of pigs with classical H1N1 and triple-reassortant H3N2 swine influenza viruses

Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses

Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail

New reassortant and enzootic European swine influenza viruses transmit efficiently through direct contact in the ferret model

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice

Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail