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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Webster, Robert G. Kim, Si-wook Kim, Myung Hee Lim, Gyo-jin Webby, Richard J. Choi, Eun Hye Yoon, Sun-woo Song, Min-suk Choi, Young-ki Lee, Ok-jun Lee, Jun Han Govorkova, Elena A. Pascua, Philippe Noriel Q. Kwon, Hyeok-il Kim, Chul-joong Park, Su-jin Baek, Yun Hee Sung, Moon Hee |
| Description | Author Affiliation: Pascua PN ( College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-763, Republic of Korea.); |
| Abstract | Efficient worldwide swine surveillance for influenza A viruses is urgently needed; the emergence of a novel reassortant pandemic H1N1 (pH1N1) virus in 2009 demonstrated that swine can be the direct source of pandemic influenza and that the pandemic potential of viruses prevalent in swine populations must be monitored. We used the ferret model to assess the pathogenicity and transmissibility of predominant Korean triple-reassortant swine (TRSw) H1N2 and H3N2 influenza viruses genetically related to North American strains. Although most of the TRSw viruses were moderately pathogenic, one [A/Swine/Korea/1204/2009; Sw/1204 (H1N2)] was virulent in ferrets, causing death within 10 d of inoculation, and was efficiently transmitted to naive contact ferrets via respiratory droplets. Although molecular analysis did not reveal known virulence markers, the Sw/1204 virus acquired mutations in hemagglutinin (HA) (Asp-225-Gly) and neuraminidase (NA) (Ser-315-Asn) proteins during the single ferret passage. The contact-Sw/1204 virus became more virulent in mice, replicated efficiently in vitro, extensively infected human lung tissues ex vivo, and maintained its ability to replicate and transmit in swine. Reverse-genetics studies further indicated that the $HA_{225G}$ and $NA_{315N}$ substitutions contributed substantially in altering virulence and transmissibility. These findings support the continuing threat of some field TRSw viruses to human and animal health, reviving concerns on the capacity of pigs to create future pandemic viruses. Apart from warranting continued and enhanced global surveillance, this study also provides evidence on the emerging roles of $HA_{225G}$ and $NA_{315N}$ as potential virulence markers in mammals. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Ferrets Virology Hemagglutinin Glycoproteins, Influenza Virus Metabolism Influenza A Virus, H1N2 Subtype Pathogenicity Mutation Orthomyxoviridae Infections Transmission Veterinary Swine Virulence Factors Animals Cell Line Genetics Mice Swine Diseases Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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