NDLI: Potyviruses differ in their requirement for TOR signalling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ouibrahim, Laurence Rubio, Ana Giner Moretti, André Montané, Marie-Hélène Menand, Benoît Meyer, Christian Robaglia, Christophe Caranta, Carole
Description	Author Affiliation: Ouibrahim L ( 3âCNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France 4âCEA, IBEB, Marseille F-13009, France 1âGenetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France 2âAix-Marseille Université, Laboratoire de Géné); Rubio AG ( 1âGenetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.); Moretti A ( 1âGenetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.); Montané MH ( 2âAix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France 3âCNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France 4âCEA, IBEB, Marseille F-13009, France.); Menand B ( 2âAix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France 3âCNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France 4âCEA, IBEB, Marseille F-13009, France.); Meyer C ( 5âInstitut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Institut National de la Recherche Agronomique AgroParisTech, Versailles cedex 78026, France.); Robaglia C ( 4âCEA, IBEB, Marseille F-13009, France 2âAix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France 3âCNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France.); Caranta C ( 1âGenetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.)
Abstract	Potyviruses are important plant pathogens that rely on many plant cellular processes for successful infection. TOR (target of rapamycin) signalling is a key eukaryotic energy-signalling pathway controlling many cellular processes such as translation and autophagy. The dependence of potyviruses on active TOR signalling was examined. Arabidopsis lines downregulated for TOR by RNAi were challenged with the potyviruses watermelon mosaic virus (WMV) and turnip mosaic virus (TuMV). WMV accumulation was found to be severely altered while TuMV accumulation was only slightly delayed. In another approach, using AZD-8055, an active site inhibitor of the TOR kinase, WMV infection was found to be strongly affected. Moreover, AZD-8055 application can cure WMV infection. In contrast, TuMV infection was not affected by AZD-8055. This suggests that potyviruses have different cellular requirements for active plant TOR signalling.
File Format	HTM / HTML
ISSN	00221317
Issue Number	9
Volume Number	96
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Comparative Study Phosphatidylinositol 3-kinases Signal Transduction Discipline Virology Arabidopsis Metabolism Journal Article Virology Arabidopsis Proteins Classification Genetics Physiology Plant Diseases Potyvirus
Content Type	Text
Resource Type	Article
Subject	Virology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in