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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chikowore, Tinashe Van Zyl, Tertia Feskens, Edith J. M. Conradie, Karin R. |
| Description | Author Affiliation: Chikowore T ( Centre for Excellence in Nutrition, North-West University, Potchefstroom, North West Province 2520, South Africa. Electronic address: tinashedoc@gmail.com.); van Zyl T ( Centre for Excellence in Nutrition, North-West University, Potchefstroom, North West Province 2520, South Africa.); Feskens EJ ( Wageningen University, Division of Human Nutrition, P.O. Box 17, 6700 AA Wageningen, The Netherlands.); Conradie KR ( Centre for Excellence in Nutrition, North-West University, Potchefstroom, North West Province 2520, South Africa.) |
| Abstract | AIMS: To determine the predictive utility of polygenic risk scores of common variants associated with type 2 diabetes derived from the European and Asian ethnicities among a black South African population. METHOD: Our study was a case-control study nested within the Prospective Urban and Rural Epidemiological (PURE) study of 178 male and female cases, matched for age and gender with 178 controls. Four types of genetic risk scores (GRS) were developed from 66 selected SNPs. These comprised of beta cell related variants (GRSb), variants which had significant associations with T2D in our study (GRSn), variants from the trans-ethnic meta-analysis (GRStrans) and all the 66 selected SNPs (GRSt). RESULTS: Of the GRS's, only GRSn was associated with increased risk of T2D as indicated by an OR (95CI) of 1.21 (1.02-1.43) p-value=0.015. Stratified analysis of age and BMI, indicated the GRSn to be significantly associated with T2D among the non-obese and participants less than 50years. The area under the ROC of the T2D risk factors only was 0.652 (p value<0.001) and with the addition of GRSn it was 0.665 (p value<0.001). CONCLUSIONS: The GRS of European and Asian derived variants have limited clinical utility in the black South African population. The inclusion of population specific variants in the GRS is pivotal. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 122 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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