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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Nianhong Zhang, Junqing Wu, Yiming Liu, Jia Liu, Lin Guo, Xiaohui |
| Description | Country affiliation: China Author Affiliation: Wang N ( Department of Medicine, Tsinghua University Hospital, Beijing 100084, China.); Zhang J ( Department of Endocrinology, Peking University First Hospital, Beijing 100034, China. Electronic address: junqingzhang126@126.com.); Wu Y ( Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.); Liu J ( Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.); Liu L ( Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.); Guo X ( Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.) |
| Abstract | OBJECTIVE: This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders. METHODS: 30 OLETF rats served as research subjects and 18 LETO rats of the same strain served as the control group (LETO group). After the first oral glucose tolerance test (at 8-week-old), 6 rats were randomly killed from each group. The remaining 24 OLETF rats were randomly divided into untreated group (OLETF group) and treated group (OLETF/M group, cured with metformin). By the end of the 10th and 20th week of treatment, MTP in the liver was measured for all rats in the study. RESULTS: All OLETF rats exhibited diabetic phenotypes at 18-week-old, with their triglyceride level higher than in LETO rats at the same age. In OLETF rats, MTP level in the liver was higher than in LETO rats at 18-week-old, and the difference was significant at 28-week-old [(13.79±1.47) vs. (8.20±1.14), p<0.05]. Treatment with metformin for 20weeks decreased triglyceride [(1.06±0.23) vs. (2.20±0.62) mmol/L, p<0.05] and total cholesterol [(1.90±0.19) vs. (2.36±0.14) mmol/L, p<0.05] in OLETF rats. Metformin also decreased MTP level in the liver [(7.65±1.31) vs. (13.79±1.47), p<0.01]. CONCLUSIONS: MTP may be associated with the lipid metabolism disorder in OLETF rats and metformin could improve lipid metabolism through reducing the expression of MTP. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 122 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-15 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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