NDLI: Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status

Please wait, while we are loading the content...

Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status

Content Provider	SAGE Publishing
Author	Layton, Jill Li, Xiaochen Shen, Changyu Groot, Mary De Lange, Leslie Correa, Adolfo Wessel, Jennifer
Copyright Year	2018
Abstract	The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1179551417748942?download=true
ISSN	11795514
Volume Number	11
Journal	Clinical Medicine Insights: Endocrinology and Diabetes (END)
e-ISSN	11795514
DOI	10.1177/1179551417748942
Language	English
Publisher	Sage Publications UK
Publisher Date	2018-01-03
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2018
Subject Keyword	Type 2 diabetes risk prediction genetic risk factors African American health genetic epidemiology
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Are the 2005 Dietary Guidelines for Americans Associated With Reduced Risk of Type 2 Diabetes and Cardiometabolic Risk Factors?

Risk scores for predicting type 2 diabetes: using the optimal tool

Are the 2005 Dietary Guidelines for Americans Associated With Reduced Risk of Type 2 Diabetes and Cardiometabolic Risk Factors?: Twenty-year findings from the CARDIA study

Genetic risk scores: are they important for diabetes management? results from multiple cross-sectional studies

Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models

Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models

Genetic Risk Assessment of Type 2 Diabetes–Associated Polymorphisms in African Americans

Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals

Identification of patient-centered outcomes among African American women with type 2 diabetes.

Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status

Similar Documents

Are the 2005 Dietary Guidelines for Americans Associated With Reduced Risk of Type 2 Diabetes and Cardiometabolic Risk Factors?

Risk scores for predicting type 2 diabetes: using the optimal tool

Are the 2005 Dietary Guidelines for Americans Associated With Reduced Risk of Type 2 Diabetes and Cardiometabolic Risk Factors?: Twenty-year findings from the CARDIA study

Genetic risk scores: are they important for diabetes management? results from multiple cross-sectional studies

Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models

Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models

Genetic Risk Assessment of Type 2 Diabetes–Associated Polymorphisms in African Americans

Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals

Identification of patient-centered outcomes among African American women with type 2 diabetes.

Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status