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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sethi, Itty Bhat, G. R. Singh, Vinod Kumar, Rakesh Bhanwer, A. J. S. Bamezai, Rameshwar N. K. Sharma, Swarkar Rai, Ekta |
| Description | Country affiliation: India Author Affiliation: Sethi I ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India.); Bhat GR ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India.); Singh V ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India.); Kumar R ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India.); Bhanwer AJ ( Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab 143005, India.); Bamezai RN ( National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.); Sharma S ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India. Electronic address: swarkar.sharma@smvdu.ac.in.); Rai E ( Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University Katra, J&K 182320, India. Electronic address: ekta.rai@smvdu.ac.in.) |
| Abstract | Type 2 Diabetes Mellitus (T2DM), a multifactorial complex disorder, is emerging as a major cause of morbidity, mortality and socio-economic burden across the world. Despite huge efforts in understanding genetics of T2DM, only â¼10% of the genetic factors have been identified so far. Telomere attrition, a natural phenomenon has recently emerged in understanding the pathophysiology of T2DM. It has been indicated that Telomeres and associated pathways might be the critical components in the disease etiology, though the mechanism(s) involved are not clear. Recent Genome Wide (GWAS) and Candidate Gene Case-Control Association Studies have also indicated an association of Telomere and associated pathways related genes with T2DM. Single Nucleotide Polymorphisms (SNPs) in the telomere maintenance genes: TERT, TERC, TNKS, CSNK2A2, TEP1, ACD, TRF1 and TRF2, have shown strong association with telomere attrition in T2DM and its pathophysiology, in these studies. However, the assessment has been made within limited ethnicities (Caucasians, Han Chinese cohort and Punjabi Sikhs from South Asia), warranting the study of such associations in different ethnic groups. Here, we propose the possible mechanisms, in the light of existing knowledge, to understand the association of T2DM with telomeres and associated pathways. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 122 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-21 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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