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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Szulc, Pawel Amri, Ez Zoubir Varennes, Annie Panaia-Ferrari, Patricia Fontas, Eric Goudable, Joëlle Chapurlat, Roland Breuil, Véronique |
| Description | Author Affiliation: Szulc P ( INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France. Electronic address: pawel.szulc@inserm.fr.); Amri EZ ( CNRS, iBV UMR 7277, Université Nice Sophia Antipolis, Parc Valrose Nice, France); Varennes A ( Department of Biochemistry and Molecular Biology, Laboratory of Medical Biology, Hospices Civils de Lyon, Lyon, France.); Panaia-Ferrari P ( Nice University Hospital, Saint Roch Hospital, Department of Hormonology, Nice, France.); Fontas E ( Nice University Hospital, Cimiez Hospital, Department of Clinical Research, Nice, France.); Goudable J ( Dept. of Public Health, University of Lyon, Hospices Civils de Lyon, Lyon, France.); Chapurlat R ( INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France.); Breuil V ( Nice University Hospital, Pasteur Hospital, Department of Rheumatology, Nice, France) |
| Abstract | AIM: Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men. METHODS: Cross-sectional study was performed in 540 volunteer men aged 50-85yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition. RESULTS: Serum oxytocin was higher in 166 men with MetS vs. controls (p<0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR=1.38 per SD, 95%CI: 1.10-1.71, p<0.005). Men with serum oxytocin >0.74pg/mL (median) had higher odds of MetS vs. men with oxytocin ⩽0.74pg/mL (OR=2.06, 95%CI: 1.33-3.18, p<0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin >0.74pg/mL and total testosterone <300ng/dL (<10.4nmol/L) had higher odds of MetS vs. men without these characteristics (OR=3.95, 95%CI: 1.65-9.46, p<0.005). Men having 25-hydroxycholecalciferol levels <30ng/mL and oxytocin >0.74pg/mL had higher odds of MetS vs. men without these characteristics (OR=2.86, 95%CI: 1.47-5.58, p<0.01). Men having oxytocin >0.74pg/mL and osteocalcin levels <14.6ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR=4.12, 95%CI: 2.07-8.20, p<0.001). CONCLUSION: In older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 122 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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