NDLI: Determinants of the decision to accept a kidney from a donor at increased risk for blood-borne viral infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reese, Peter P. Tehrani, Tara Lim, Mary Ann Asch, David A. Blumberg, Emily A. Simon, Maureen K. Bloom, Roy D. Halpern, Scott D.
Spatial Coverage	Pennsylvania
Description	Country affiliation: United States Author Affiliation: Reese PP ( University of Pennsylvania, Renal Division, Department of Medicine, Philadelphia, PA, USA. peter.reese@uphs.upenn.edu)
Abstract	BACKGROUND AND OBJECTIVES: The use of kidneys from donors at increased risk for viral infections (DIRVI) such as HIV could increase the number of transplants and decrease waiting times. This study aimed to identify the proportion of kidney transplant candidates that would accept a kidney from a DIRVI and the factors that influenced this decision. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Conjoint analysis was used to assess the conditions in which renal transplant candidates would accept a DIRVI kidney. Candidates completed 12 scenarios in which the waiting time for a kidney, the donor age as a surrogate for kidney quality, and the risk of contracting HIV were systematically varied. RESULTS: Among 175 respondents, 42 (24.0%) rejected DIRVI kidneys under all conditions, 103 (58.9%) accepted DIRVI kidneys under some conditions, and 31 (17.7%) always accepted DIRVI kidneys. In multivariable logistic regression, patients were more likely to accept a DIRVI kidney when waiting time was longer, the donor was younger, and HIV risk was lower (P < 0.01 for each variable). Patients on dialysis (P < 0.01) and older patients (P = 0.04) more commonly accepted DIRVI kidneys, but self-rated sense of health was not associated with DIRVI kidney acceptance. CONCLUSIONS: Most renal transplant candidates would accept a DIRVI kidney under some circumstances. These findings suggest that recipients can be allowed to make prospective choices regarding DIRVI kidney acceptance without hindering placement of these organs.
File Format	HTM / HTML
ISSN	15559041
e-ISSN	1555905X
DOI	10.2215/CJN.08251109
Journal	Clinical Journal of the American Society of Nephrology
Issue Number	5
Volume Number	5
Language	English
Publisher	American Society of Nephrology
Publisher Date	2010-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chi-square Distribution Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Cross-sectional Studies Psychology Patient Acceptance Of Health Care Etiology Surgery Questionnaires Waiting Lists Supply & Distribution Adverse Effects Choice Behavior Risk Assessment Risk Factors Discipline Nephrology Logistic Models Kidney Transplantation Hiv Infections Health Knowledge, Attitudes, Practice Pennsylvania Adolescent Kidney Failure, Chronic Tissue Donors
Content Type	Text
Resource Type	Article
Subject	Transplantation Critical Care and Intensive Care Medicine Nephrology Epidemiology

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