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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Caroli, Anna Antiga, Luca Cafaro, Mariateresa Fasolini, Giorgio Remuzzi, Andrea Remuzzi, Giuseppe Ruggenenti, Piero |
| Description | Country affiliation: Italy Author Affiliation: Caroli A ( Biomedical Engineering, Mario Negri Institute for Pharmacological Research, Via Gavazzeni, 11, 24125 Bergamo, Italy.) |
| Abstract | BACKGROUND AND OBJECTIVES: No medical treatment is available for polycystic liver disease, a frequent manifestation of autosomal-dominant polycystic kidney disease (ADPKD). In a prospective, randomized, double-blind, crossover study, 6 months of octreotide (40 mg every 28 days) therapy limited kidney volume growth more effectively than placebo in 12 patients with ADPKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this secondary, post hoc analysis of the above study, octreotide-induced changes in liver volumes compared with placebo and the relationship between concomitant changes in liver and kidney volumes were evaluated. Those analyzing liver and kidney volumes were blinded to treatment. RESULTS: Liver volumes significantly decreased from 1595 +/- 478 ml to 1524 +/- 453 ml with octreotide whereas they did not appreciably change with placebo. Changes in liver volumes were significantly different between the two treatment periods (-71 +/- 57 ml versus +14 +/- 85 ml). Octreotide-induced liver volume reduction was fully explained by a reduction in parenchyma volume from 1506 +/- 431 ml to 1432 +/- 403 ml. Changes in liver volumes were significantly correlated with concomitant changes in kidney volumes (r = 0.67) during octreotide but not during placebo treatment. Liver and kidney volume changes significantly differed with both treatments (octreotide: -71 +/- 57 ml versus +71 +/- 107; placebo: +14 +/- 85 ml versus +162 +/- 114), but net reductions in liver (-85 +/- 103 ml) and kidney (-91 +/- 125 ml) volume growth on octreotide versus placebo were similar. CONCLUSIONS: Octreotide therapy reduces liver volumes in patients with ADPKD and is safe. |
| File Format | HTM / HTML |
| ISSN | 15559041 |
| e-ISSN | 1555905X |
| DOI | 10.2215/CJN.05380709 |
| Journal | Clinical Journal of the American Society of Nephrology |
| Issue Number | 5 |
| Volume Number | 5 |
| Language | English |
| Publisher | American Society of Nephrology |
| Publisher Date | 2010-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Prospective Studies Cross-over Studies Liver Octreotide Double-blind Method Tomography, Spiral Computed Kidney Time Factors Etiology Adverse Effects Polycystic Kidney Diseases Complications Drug Therapy Discipline Nephrology Randomized Controlled Trial Drug Effects Therapeutic Use Cysts Liver Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Critical Care and Intensive Care Medicine Nephrology Epidemiology |
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