NDLI: Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Haymann, Jean-Philippe Stankovic, Katia Levy, Pierre Avellino, Virginie Tharaux, Pierre-Louis Letavernier, Emmanuel Grateau, Gilles Baud, Laurent Girot, Robert Lionnet, François
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Haymann JP ( Université Pierre et Marie Curie, Université Paris 6, Institut National de la Santé et de la Recherche Médicale Unit 702, Physiology, Paris, France. jean-philippe.haymann@tnn.aphp.fr)
Abstract	BACKGROUND AND OBJECTIVES: Sickle cell anemia-associated nephropathy is a growing matter of concern because renal failure affects most aging sickle cell anemia patients. Glomerular damage is a common feature revealed by a microalbuminuria or a macroalbuminuria. Although glomerular hyperfiltration has been described for decades in this population, its prevalence in young adults is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To address this issue, as well as the clinical and biologic correlates of hyperfiltration, a single-center, cross-sectional study of 280 homozygous SS disease patients was performed. RESULTS: The prevalence of hyperfiltration assessed by Modification of Diet in Renal Disease estimated GFR was 51%. Among patients with hyperfiltration, 49% had hyperfiltration alone, whereas 36% and 15% had an associated microalbuminuria or macroalbuminuria, respectively. Estimated GFR sensitivity and specificity for hyperfiltration were 94% and 63%, respectively, in a selected subgroup of 48 patients (measured GFR was assessed by urinary (51)Cr EDTA clearance). In patients with no albuminuria, hyperfiltration status was significantly associated with a young age (years), the absence of alpha thalassemia, a lower hemoglobin level (g/dl), and a lower fetal hemoglobin. The role of chronic hemolysis was further strengthened by multivariate analysis showing a correlation between estimated GFR and a low plasma fetal hemoglobin level, a young age, and a high reticulocyte count (r(2) = 0.54). CONCLUSIONS: Together, the data suggest that the pathophysiology of hyperfiltration would rather be attributable to the hemolysis-associated vasculopathy rather than a viscosity-vaso-occlusive process.
File Format	HTM / HTML
ISSN	15559041
e-ISSN	1555905X
DOI	10.2215/CJN.08511109
Journal	Clinical Journal of the American Society of Nephrology
Issue Number	5
Volume Number	5
Language	English
Publisher	American Society of Nephrology
Publisher Date	2010-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anemia, Sickle Cell Cross-sectional Studies Albuminuria Epidemiology Kidney Blood Renal Insufficiency Genetics Hemoglobin, Sickle Hemolysis Glomerular Filtration Rate Risk Assessment Risk Factors Discipline Nephrology Linear Models Logistic Models Physiopathology Homozygote Adolescent
Content Type	Text
Resource Type	Article
Subject	Transplantation Critical Care and Intensive Care Medicine Nephrology Epidemiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Chronic kidney disease and albuminuria in children with sickle cell disease.

Glomerular Hyperfiltration in Adult Sickle Cell Anemia: A Frequent Hemolysis Associated Feature

A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.

Changes in Albuminuria and Subsequent Risk of Incident Kidney Disease

Cystatin C levels in U.S. adults, 1988-1994 versus 1999-2002: NHANES.

Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study.

Relationship between GFR and albuminuria in stage 1 hypertension.

Sickle cell trait and development of microvascular complications in diabetes mellitus.

Prevalence and correlates of metabolic acidosis among patients with homozygous sickle cell disease.

Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature.

Similar Documents

Chronic kidney disease and albuminuria in children with sickle cell disease.

Glomerular Hyperfiltration in Adult Sickle Cell Anemia: A Frequent Hemolysis Associated Feature

A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.

Changes in Albuminuria and Subsequent Risk of Incident Kidney Disease

Cystatin C levels in U.S. adults, 1988-1994 versus 1999-2002: NHANES.

Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study.

Relationship between GFR and albuminuria in stage 1 hypertension.

Sickle cell trait and development of microvascular complications in diabetes mellitus.

Prevalence and correlates of metabolic acidosis among patients with homozygous sickle cell disease.

Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature.