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Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baraldi, Flavia Dalalio, Felipe Teodoro, Bruno Prado, Ieda Curti, Carlos Alberici, Luciane
Description	Country affiliation: Brazil Author Affiliation: Baraldi F ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil.); Dalalio F ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil.); Teodoro B ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil.); Prado I ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil.); Curti C ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil.); Alberici L ( Universidade de So Paulo (Faculdade de Cincias Farmacuticas de Ribeiro Preto), Departamento de Fsica e Qumica, Brazil. Electronic address: alberici@fcfrp.usp.br.)
Abstract	INTRODUCTION: Some fatty acids may play an important role in regulating metabolism through PPARs activation. Conjugated linoleic acid (CLA) has been shown to reduce body fat accumulation and increase body metabolism; this effect has been associated with up-regulation of mitochondrial uncoupling proteins (UCPs) and PPARalfa activation. Oleic acid has shown beneficial effects on health, decreasing oxidative stress and improving clinical conditions related to obesity. Therefore, in this work, we addressed the effects of a oleic plus CLA-supplemented murine diet on body metabolism, mitochondrial energetics and oxidative stress in the liver, as well as on other associated morphological and functional parameters in C57BL/6 mice. METHOD: The diet was supplemented with 2% CLA mixture (cis-9, trans-10 and trans-10, cis-12 isomers; 45% of each isomer) and/or 0.7% olive oil on alternating days (60 days) by gavage. RESULTS: The results showed that diet supplementation with CLA increases body metabolism and reduces lipid accumulation in adipose tissues. Groups that received oleic acid (oleic and CLA oleic) showed decreased levels of total cholesterol and cholesterol non-HDL, and increased levels of HDL-cholesterol. Livers of mice fed a diet supplemented with CLA showed high levels UCP2 mRNA, and the isolated hepatic mitochondria showed indications of UCP activity and increased ROS generation. Oleic acid partially reversed the lower lipid accumulation increasing PPARgamma content, reversed the higher ROS generation by liver mitochondria and improved liver oxidative status. CONCLUSIONS: These results indicate a beneficial and secure dose of CLA and oleic acid for diet supplementation in mice, which increases body metabolism inducing UCP2 overexpression/activity in liver while preserving the redox state of the liver. Therefore, diet supplementation with CLA associated to oleic acid may be regarded as a potential strategy for controlling obesity and oxidative stress. Supported by FAPESP.
File Format	HTM / HTML
ISSN	08915849
Issue Number	Suppl 1
Journal	Free Radical Biology and Medicine
Volume Number	75
e-ISSN	18734596
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

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