NDLI: Long-lived reactive species formed on proteins induce changes in protein and lipid turnover.

Please wait, while we are loading the content...

Year: 2017 Volume: 106

Year: 2017 Volume: 104

Year: 2017 Volume: 103

Year: 2017 Volume: 102

Year: 2016 Volume: 102

Year: 2016 Volume: 101

Year: 2016 Volume: 100

Year: 2016 Volume: 100S

Year: 2016 Volume: 99

Year: 2016 Volume: 98

Year: 2016 Volume: 97

Year: 2016 Volume: 96

Year: 2016 Volume: 95

Year: 2016 Volume: 94

Year: 2016 Volume: 93

Year: 2016 Volume: 92

Year: 2016 Volume: 91

Year: 2016 Volume: 90

Year: 2015 Volume: 89

Year: 2015 Volume: 88

Year: 2015 Volume: 87

Year: 2015 Volume: 86

Year: 2015 Volume: 85

Year: 2015 Volume: 84

Year: 2015 Volume: 83

Year: 2015 Volume: 82

Year: 2015 Volume: 81

Year: 2015 Volume: 80

Year: 2015 Volume: 79

Year: 2015 Volume: 78

Year: 2014 Volume: 77

Year: 2014 Volume: 76

Year: 2014 Volume: 75

Year: 2014 Volume: 75 Issue: Supplementary 1

Antioxidants in skeletal muscle physiology, a radically different approach.

Nrf2-mediated redox signalling in vascular health and disease.

CD36 as a biomarker of atherosclerosis.

Fibroblasts from skin biopsies as a tool for biomarker discovery in Parkinson×³s disease.

Scavenger Receptor B1 oxidative post-translational modifications are responsible for its loss in Rett syndrome.

Proteomics to Understand the Degenerative Matter.

Nutrigenomic programming of cardiovascular and metabolic diseases.

MicroRNAs as novel nutrigenomic targets for cardiovascular health.

Role of polyphenols in improving endothelial dysfunction in diabetes.

Flavanols and vascular health: molecular mechanisms to build evidence-based recommendations.

Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.

Akt mediated ROS-dependent selective targeting of mutant KRAS tumors.

SFRR-E Young Investigator Awardee B-crystallin modulation after acute exercise in skeletal muscle: the role of oxidative stress and fiber composition.

Induction of antioxidant genes by sulforaphane and klotho in human aortic smooth muscle cells.

Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation.

Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation: Could protein S-nitrosylation be the unifying oxidative modification to explain the cellular signaling activity of superoxide and hydrogen peroxide?

Oxidised LDL lipids, statins and a blood-brain barrier.

Protein and lipid carbonylation in cellular model of nitrosative stress: mass spectrometry, biochemistry and microscopy study.

Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages.

The effect of Irisin on antioxidant system in liver.

SFRR-E Young Investigator AwardeeNOXing out stroke: Identification of NOX4 and 5as targets in blood-brain-barrier stabilisation and neuroprotection.

Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease.

Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies.

Circadian modulation of proteasome activities and removal of carbonylated proteins.

p38 deficiency and oxidative stress cause cytokinesis failure in hepatocytes.

Skin protection against dicarbonyl stress by the glyoxalase system.

The antioxidative effect of bread crust in a mouse macrophage reporter cell line.

Oxidative degradation pathways of cellular DNA: product formation and mechanistic insights.

Redox Dysregulation in Vascular Pathobiology.

Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid.

In vitro glycation and glycoxidation of phosphatidylethanolamines.

Antioxidants and muscle atrophy in colon cancer: beneficial or deleterious effects?

Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans.

AF-1 a novel regulator of the redox equilibrium during aging.

Is Peroxiredoxin II's peroxidase activity strongly inhibited in human erythrocytes?

Impaired metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes.

Oxi-DIGE: A novel proteomic approach for detecting and quantifying carbonylated proteins.

The role of hypercholesterolemic diet and vitamin E on Nrf2 pathway, endoplasmic reticulum stress and proteasome activity.

HSP90 cleavage associates with oxidized proteins accumulation after oxidative stress.

Is the Peroxiredoxin 2/Thioredoxin/Thioredoxin Reductase system in human erythrocytes designed for redox signaling?

Glutathione is essential to preserve nuclear function and cell survival under oxidative stress.

Interplay between selenium levels, selenoprotein expression, and replicative senescence in WI-38 human fibroblasts.

Selective up-regulation of human selenoproteins in response to oxidative stress.

Glyoxalase II promotes 'in vitro' S-glutathionylation.

Vismia cauliflora extracts: bioactive compounds and the in vitro scavenging capacity against reactive oxygen and nitrogen species.

Production of natural IgM antibodies against oxidatively-modified proteins in milk fat globule epidermal growth factor 8 (MFG-E8) deficient mice.

The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines.

Quantification of Carnosine-Aldehyde Adducts in Human Urine.

Disruption of the iron-sulfur cluster of aconitase by myeloperoxidase-derived oxidants.

Singlet molecular oxygen generated in dark biological process.

De novo ceramides synthesis is not involved in skeletal muscle atrophy induced by short-term mechanical unloading.

Hypercholesterolemia as a risk factor for depressive disorder?

Acute Electrical Pulse Stimulation and Hyperglycemia Regulates RCAN1-4 in C2C12 myotubes through Oxidative Stress.

Effect of novel 1-phenyl-3-methyl-4-acylpyrazolones on iron chelation and Fenton reaction.

Paraoxonase 1 and HDL subfractions in hypercholesterolemic children and adolescents.

Glutathione and NADPH in plant responses to H2O2.

Transport of glutathione into the nucleus.

Glutathione and cellular redox control in epigenetic regulation.

Anti-inflammatory and pro-apoptotic activities of chlorinated flavonoids in human neutrophils.

N-acetylcysteine protects the rat kidney against aspartame-induced oxidative stress.

A1M, an extravascular tissue cleaning and housekeeping protein: a possible drug candidate.

Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/ inhibitors in non-small cell lung cancer tissue.

Optimization of in vitro measurement of proteasome activity in mammalian cells using fluorogenic substrates.

Macrophage polarisation by fatty acids is PPARgamma-dependent.

Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice.

Effects of Lon protease down-regulation on the mitochondrial function and proteome.

TNF-a stimulation enhances ROS-dependent cell migration via NF-?B activation in liver cells.

Monitoring dynamic changes of glutathione redox state in subcellular compartments of human cells - an approach based on rxYFP biosensor.

Investigating free radical generation in HepG2 cells using immuno-spin trapping.

Hydroxybenzoic acids and their derivatives as peroxynitrite scavengers.

The skin autofluorescence reflects the posttranslational glycation grade of the matrix protein collagen.

Reactive oxygen species and PI3K/Akt signaling in cancer.

Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita.

Heat shock proteins and proteasomal degradation in normal and tumor cells.

The modified proteins in erythrocytes at hemodialysis patients.

Characteristic of oxidative metabolism in patients with chronic kidney disease depending on etiological nosology.

A dietary-driven redox modulation of gut microbiome-host interactions: the rescue of epithelial barrier and mucus production during dysbiosis by dietary nitrate.

Endogenous intoxication in helminthic invasion in men of reproductive age.

The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.

Evaluation of Mitochondrial Function in the CNS of Rodent Models of Alzheimer's Disease - High Resolution Respirometry Applied to Acute Hippocampal Slices.

Pitx2 and Pitx3 transcription factors: two key regulators of the redox state in adult skeletal muscle stem cells and muscle regeneration.

Consumption of peptide-included and free tryptophan induced by peroxyl radicals: A kinetic study.

Characterization of the NF-?B signaling triggered by doxorubicin.

Role of alkoxyl radicals on the fluorescein-based ORAC (Oxygen Radical Absorbance Capacity) assay.

Pepper fruit as a model to study the metabolism of antioxidants, ROS and RNS.

Role of Oxidized Protein Repair in Human Skeletal Muscle.

Characterization of Antioxidant Enzymes and Peroxisomes of Olive (Olea europaea L.) Fruits.

The E3 ubiquitin ligase APC/C-Cdh1 coordinates neurogenesis and cortical size during development.

Regulation and involvement of the ubiquitin ligases in muscle atrophy.

APC/Cdh E3 ubiquitin ligase in the pathophysiology of Alzheimer×³s disease.

TGFß1 rapidly activates Src through a non-canonical redox mechanism.

Inflammation-Enhanced Drug-Induced Liver Injury.

Hepatocellular carcinoma protein carbonylation in virus C and metabolic syndrome patients.

Diphenyl diselenide improves the antioxidant response via activation of the Nrf-2 pathway in macrophage cells.

Quantification of DNA adducts in lungs, liver and brain of rats exposed to acetaldehyde.

Glutathione S-transferase activity in follicular fluid from women undergoing ovarian stimulation: role in maturation.

Characterization of the paraoxonase system in follicular fluid of women subjected to an ovarian stimulation cycle.

Myeloperoxidase activity and the oxidized proteins in blood neutrophils of patients with pneumonia.

The effect of natural polyphenols on the oxidative stress markers in patients with diabetic nephropathy.

The relationship of oxidative stress markers and parameters of myocardial function in a rat model of cardiotoxicity.

Vasodilatory activity of human quercitin metabolites.

Redox regulation of E3 ubiquitin ligases and their role in skeletal muscle atrophy.

The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells.

The Relations Between Immunity, Oxidative Stress and Inflammation Markers, in Childhood Obesity.

Detection and quantification of protein oxidation in sarcopenic models: a mass spectrometry study.

Pancreatic ascites haemoglobin up-regulates the HIF/VEGF pathway in the lung in severe acute pancreatitis.

Stem bark and flower extracts of Vismia cauliflora: modulation of oxidative burst in human neutrophils' and inhibition of oxidative damage in human erythrocytes.

Innovative anthocyanins formulation protects neuronal-like cells against oxidative stress-induced damage: Pharmacotherapeutic application for Alzheimer's disease.

Can semi-synthetic flavonoids return old microglia to their youthful state?

Flavonoids inhibit the production of cytokines/chemokines and induce apoptosis in human neutrophils.

In vitro copper-chelating properties of flavonoids.

Measuring site occupancy: a new perspective on cysteine oxidation.

Integration between anticipatory blocking and redox signaling by the peroxiredoxin/thioredoxin/thioredoxin-reductase system.

Increased oxidative stress and impaired antioxidant response in Lafora disease.

Polyphenols protect against protein glycoxidation.

Regulation of inflammatory pathways by an a-tocopherol long-chain metabolite and a d-tocotrienol-related natural compound.

Biomarkers research in neuromuscular disease Charcot-Marie-Tooth.

Organizing principles underlying microorganism's growth-robustness trade-off.

Lipid peroxidation in Rheumatoid arthritis; consequences and monitoring.

15-deoxy-?(12,14)-prostaglandin J2 as a potential TRPV1-dependent atopic dermatitis enhancer.

Modulation of cell signaling pathways by oxysterols in age-related human diseases.

Control of endothelial function and angiogenesis by PGC-1 relies on ROS control of vascular stability.

Involvement of E3 Ubiquitin ligases in Cigarette Smoke associated muscle catabolism.

Cu(II)-disulfide complexes with superoxide dismutase- and catalase-like activities protect mitochondria and whole cells against oxidative stress.

Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease.

Nitric oxide affects trypomastigote to amastigote differentiation in Trypanosoma cruzi.

Assessment of an in vitro model of lung epithelial cell stress responses.

Determination of biomarkers of protein oxidation in tissue and plasma.

Oxidative stress affects FET proteins localization and alternative pre-mRNA processing in cellular models of ALS.

Psychiatric disorders and omega-3 fatty acids.

Targeted mass spectrometry methods for detecting oxidative post-translational modifications.

Long term p38-a deficiency up-regulates antioxidant enzymes through compensatory NF-?B activation.

Differential activation of neutrophil extracellular traps by specific periodontal bacteria.

Modulation of cellular thiol status affects FoxO activity and life span.

How to Write a Great Research Paper, and Get it Accepted by a Good Journal.

Long-lived reactive species formed on proteins induce changes in protein and lipid turnover.

What Goes Wrong with Lon in Ageing?

NASH (Nonalcoholic steatohepatitis): A case of multiorganelle failure.

Oxysterols in the orchestra of liver cell metabolism.

Chemical strategies and tandem mass spectrometry for the detection and identification of protein modifications by electrophilic lipoxidation products.

Protein Oxidation Products as Biomarkers.

Proteasome activation as a novel anti-aging strategy.

Selenium and Methionine Sulfoxide Reduction.

Electrophilic prostaglandins: identification of protein targets and opportunities for drug discovery.

Activation of stress signaling pathways by oxidized and nitrated lipids.

The role lipid aldehydes and ALEs in the pathogenesis of diabetic retinopathy.

Redox and zinc signalling pathways converging on protein tyrosine phosphatases.

Metal homeostasis in dementia.

Targeted deletion of Secisbp2 reduces, but does not abrogate, selenoprotein expression and leads to striatal interneuron loss.

Monoamine oxidase inhibition prevents mitochondrial dysfunction and apoptosis in myoblasts from patients with collagen VI myopathies.

Oxidized LDL lipids increase ß-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.

DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells.

Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction.

Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration.

Thioredoxin-1 Redox Signaling Regulates Cell Survival in Response to Hyperoxia

Year: 2014 Volume: 74

Year: 2014 Volume: 73

Year: 2014 Volume: 72

Year: 2014 Volume: 71

Year: 2014 Volume: 70

Year: 2014 Volume: 69

Year: 2014 Volume: 68

Year: 2014 Volume: 67

Year: 2014 Volume: 66

Year: 2013 Volume: 65

Year: 2013 Volume: 64

Year: 2013 Volume: 63

Year: 2013 Volume: 62

Year: 2013 Volume: 61

Year: 2013 Volume: 60

Year: 2013 Volume: 59

Year: 2013 Volume: 58

Year: 2013 Volume: 57

Year: 2013 Volume: 56

Year: 2013 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2012 Volume: 52

Year: 2011 Volume: 51

Year: 2011 Volume: 50

Year: 2010 Volume: 49

Year: 2010 Volume: 48

Year: 2009 Volume: 47

Year: 2009 Volume: 46

Long-lived reactive species formed on proteins induce changes in protein and lipid turnover.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Davies, Michael
Description	Country affiliation: Denmark Author Affiliation: Davies M ( University of Copenhagen (Panum Institute), Department of Biomedical Sciences, Denmark.)
Abstract	Proteins are major targets for oxidative damage in vivo due to their high abundance and rapid rates of reaction with both one-electron (radical) and two-electron oxidants (e.g. singlet oxygen, hypochlorous acid, peroxynitrous acid, reactive aldehydes). The turnover of both native and modified proteins is critical for maintenance of cell homeostasis, with this occurring via multiple pathways including proteasomes (for cytosolic species), the Lon protease (in mitochondria), and the endo-lysosomal systems (both extra- and intra-cellular species). Evidence has been presented for both enhanced and diminished rates of catabolism of modified proteins, as well as altered turnover of native (unmodified) proteins as a result of damage to these systems, potentially as a result of the accumulation of damaged proteins. In recent studies we have shown that long-lived reactive species forms on proteins (hydroperoxides, chloramines and aldehydes) can modify the activity of proteasomal and lysosomal enzymes. Some of the above species are efficient inhibitors of the tryptic and chymotryptic activities of the 26S proteasome, as well as lysosomal cathepsin and acid lipase activities. These are key species in the turnover of both proteins and lipoproteins. The loss of enzyme activity is accompanied in many cases, by oxidation of critical thiol residues via molecular reactions. For reactive aldehydes (either free or protein-bound) direct enzyme inhibition can occur as well as modulation of protein levels and, in the case of lysosomes, changes in lysosomal numbers. Overall, these data indicate that the formation of reactive species on proteins can modulate cell function by multiple pathways including interference with the turnover of native proteins (including critical cell signalling molecules) and alterations in the rate of clearance of modified proteins. Both pathways may contribute to the development of a number of human pathologies associated with oxidative damage.
File Format	HTM / HTML
ISSN	08915849
Issue Number	Suppl 1
Journal	Free Radical Biology and Medicine
Volume Number	75
e-ISSN	18734596
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in