NDLI: MicroRNAs as novel nutrigenomic targets for cardiovascular health.

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Antioxidants in skeletal muscle physiology, a radically different approach.

Nrf2-mediated redox signalling in vascular health and disease.

CD36 as a biomarker of atherosclerosis.

Fibroblasts from skin biopsies as a tool for biomarker discovery in Parkinson×³s disease.

Scavenger Receptor B1 oxidative post-translational modifications are responsible for its loss in Rett syndrome.

Proteomics to Understand the Degenerative Matter.

Nutrigenomic programming of cardiovascular and metabolic diseases.

MicroRNAs as novel nutrigenomic targets for cardiovascular health.

Role of polyphenols in improving endothelial dysfunction in diabetes.

Flavanols and vascular health: molecular mechanisms to build evidence-based recommendations.

Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.

Akt mediated ROS-dependent selective targeting of mutant KRAS tumors.

SFRR-E Young Investigator Awardee B-crystallin modulation after acute exercise in skeletal muscle: the role of oxidative stress and fiber composition.

Induction of antioxidant genes by sulforaphane and klotho in human aortic smooth muscle cells.

Oxidative stress and dystrophy Facioscapulohumeral: Effects of vitamin C, vitamin E, zinc gluconate and selenomethionine supplementation.

Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation: Could protein S-nitrosylation be the unifying oxidative modification to explain the cellular signaling activity of superoxide and hydrogen peroxide?

Oxidised LDL lipids, statins and a blood-brain barrier.

Protein and lipid carbonylation in cellular model of nitrosative stress: mass spectrometry, biochemistry and microscopy study.

Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages.

The effect of Irisin on antioxidant system in liver.

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Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease.

Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies.

Circadian modulation of proteasome activities and removal of carbonylated proteins.

p38 deficiency and oxidative stress cause cytokinesis failure in hepatocytes.

Skin protection against dicarbonyl stress by the glyoxalase system.

The antioxidative effect of bread crust in a mouse macrophage reporter cell line.

Oxidative degradation pathways of cellular DNA: product formation and mechanistic insights.

Redox Dysregulation in Vascular Pathobiology.

Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid.

In vitro glycation and glycoxidation of phosphatidylethanolamines.

Antioxidants and muscle atrophy in colon cancer: beneficial or deleterious effects?

Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans.

AF-1 a novel regulator of the redox equilibrium during aging.

Is Peroxiredoxin II's peroxidase activity strongly inhibited in human erythrocytes?

Impaired metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes.

Oxi-DIGE: A novel proteomic approach for detecting and quantifying carbonylated proteins.

The role of hypercholesterolemic diet and vitamin E on Nrf2 pathway, endoplasmic reticulum stress and proteasome activity.

HSP90 cleavage associates with oxidized proteins accumulation after oxidative stress.

Is the Peroxiredoxin 2/Thioredoxin/Thioredoxin Reductase system in human erythrocytes designed for redox signaling?

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Interplay between selenium levels, selenoprotein expression, and replicative senescence in WI-38 human fibroblasts.

Selective up-regulation of human selenoproteins in response to oxidative stress.

Glyoxalase II promotes 'in vitro' S-glutathionylation.

Vismia cauliflora extracts: bioactive compounds and the in vitro scavenging capacity against reactive oxygen and nitrogen species.

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The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines.

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Optimization of in vitro measurement of proteasome activity in mammalian cells using fluorogenic substrates.

Macrophage polarisation by fatty acids is PPARgamma-dependent.

Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice.

Effects of Lon protease down-regulation on the mitochondrial function and proteome.

TNF-a stimulation enhances ROS-dependent cell migration via NF-?B activation in liver cells.

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A dietary-driven redox modulation of gut microbiome-host interactions: the rescue of epithelial barrier and mucus production during dysbiosis by dietary nitrate.

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The effect of natural polyphenols on the oxidative stress markers in patients with diabetic nephropathy.

The relationship of oxidative stress markers and parameters of myocardial function in a rat model of cardiotoxicity.

Vasodilatory activity of human quercitin metabolites.

Redox regulation of E3 ubiquitin ligases and their role in skeletal muscle atrophy.

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Activation of stress signaling pathways by oxidized and nitrated lipids.

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Oxidized LDL lipids increase ß-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.

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MicroRNAs as novel nutrigenomic targets for cardiovascular health.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Milenkovic, Dragan
Description	Country affiliation: France Author Affiliation: Milenkovic D ( INRA, Centre de Clermont-Ferrand/Theix, Unité de Nutrition Humaine, Clermont-Ferrand, France.)
Abstract	Consumption of flavanol-rich foods is associated with a reduced risk of cardiovascular diseases, which was linked to improvements in endothelial function. The specific flavanols involved in these beneficial effects and underlying molecular mechanisms is still largely unknown. We have shown that exposure of TNF -activated endothelial cells to flavanol metabolites (4'-O-methyl(-)-epicatechin, 4'-O-methyl(-)-epicatechin-7-ß-D-glucuronide and (-)-epicatechin-4'-sulfate) at physiologically-relevant concentrations decreased the adhesion of monocytes to endothelial monolayers. Nutrigenomic analysis showed that these metabolites modulate expression of genes involved in the regulation of cell adhesion/junctions, focal adhesion or cytoskeleton remodeling, and this by affecting phosphorylation levels of p65 and p38 of NF-κB and MAPK cell-signaling pathways respectively. Together with cell signaling pathways, microRNAs (short, endogenous, noncoding, single-stranded RNAs) represent another class of molecular post-transcriptional regulators of gene expression. Our nutrigenomic studies have shown that exposure of endothelial cells to the same metabolites can also modulate the expression of miRNAs. Among differentially-expressed miRNAs are those involved in the regulation of inflammation or cell adhesion, such as miR-221 and miR-181. Bioinformatic analysis shows that the potential target genes these miRNAs are also involved in regulation of cell adhesion, cytoskeleton, focal adhesion, transendothelial migration. These miRNAs could exert post-transcriptional regulation by inhibiting protein synthesis, as BIRC2, or by inducing mRNA degradation, as WASP1.These data suggest that miRNAs are important molecular targets of flavanol metabolites involved in the regulation of expression of genes controlling adhesion and transendothelial migration processes. This original result contributes to increase the knowledge about the mechanisms underlying the protective effect of flavanols on vascular endothelium.
File Format	HTM / HTML
ISSN	08915849
Issue Number	Suppl 1
Journal	Free Radical Biology and Medicine
Volume Number	75
e-ISSN	18734596
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

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