NDLI: Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/ inhibitors in non-small cell lung cancer tissue.

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Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/ inhibitors in non-small cell lung cancer tissue.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gegotek, Agnieszka Niklinski, Jacek Charkiewicz, Radoslaw Bielawska, Katarzyna Kozlowski, Miroslaw Skrzydlewska, Elzbieta
Description	Author Affiliation: Gegotek A ( Medical University of Bialystok, Department of Analytical Chemistry, Poland. Electronic address: agnieszkagegotek@o2.pl.); Niklinski J ( Medical University of Bialystok, Department of Clinical Molecular Biology, Poland.); Charkiewicz R ( Medical University of Bialystok, Department of Clinical Molecular Biology, Poland.); Bielawska K ( Medical University of Bialystok, Department of Analytical Chemistry, Poland.); Kozlowski M ( Medical University of Bialystok, Department of Thoracic Surgery, Poland.); Skrzydlewska E ( Medical University of Bialystok, Department of Analytical Chemistry, Poland.)
Abstract	Lung cancer development is characterized by oxidative stress that leads to the oxidative modifications of cellular components, including phospholipid and protein. Lipid peroxidation products may be involved in intracellular signaling pathways or in the activity of transcription factors (Nrf2). Therefore, the aim of this study has been to evaluate the relationship between the level of reactive aldehydes and the activity of the transcription factor and a comparison of these parameters in different histological types and stages of non-small cell lung cancer. Lung cancer tissues and tissues without morphological changes were received during operation from patients with squamous cell lung carcinoma (SqCC), lung adenocarcinoma (AC) and large cell lung carcinoma (LCC). In the tissue homogenates the level of reactive aldehydes [4-HNE, MDA, 4-ONE] was determined by GCMS, while Nrf2 and its activators/inhibitors were evaluated by Western immunobloting. Tumor tissues showed several times higher reactive aldehydes level and those changes were accompanied by overexpression of Nrf2. The highest increase of 4-HNE and MDA level was observed in the SqCC and it was correlated with the highest increase in Nrf2 expression. Moreover, the aldehydes level and Nrf2 phosphorylation were significantly higher in the stage I than in the stage II. The level of Nrf2 inhibitor - Bach1 was lower in all histological types of tumor, but in AC was the most reduced, what is correlated with the lowest level of reactive aldehydes. The highest expression of p62 and p21 - Nrf2 activators was observed also in adenocarcinoma of the lung. However, the level of another Nrf2 activator - KAP1 was decreased in all histological types of tumor. Additionally, the cJun amount in the tumor tissue was increased, whereas reduction of its phosphorylated form in AC and LCC was observed. Understanding the relation between reactive aldehydes level and the Nrf2 activity may be applied in anticancer therapies.
File Format	HTM / HTML
ISSN	08915849
Issue Number	Suppl 1
Journal	Free Radical Biology and Medicine
Volume Number	75
e-ISSN	18734596
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

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